Wakefulness promoting drug/Dopamine reuptake inhibitor
CRL-40,940
(2-Amino-2-oxoethyl)[bis(4-fluorophenyl)methyl]sulfoniumolate
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) Formula C 15 H 13 F 2 N O 2 S Molar mass 309.33 g·mol−1 3D model (JSmol )
C1=CC(=CC=C1C(C2=CC=C(C=C2)F)S(=O)CC(=O)N)F
InChI=1S/C15H13F2NO2S/c16-12-5-1-10(2-6-12)15(21(20)9-14(18)19)11-3-7-13(17)8-4-11/h1-8,15H,9H2,(H2,18,19)
Key:YEAQNUMCWMRYMU-UHFFFAOYSA-N
CRL-40,940 (also known as flmodafinil , bisfluoromodafinil and lauflumide ) is the bisfluoro analog of modafinil .[1] [2] [3] [4] It is a eugeroic as well as a weak dopamine reuptake inhibitor . Its inventors claim that it is more effective than modafinil and adrafinil, with fewer side effects. It was patented in 2013, and pre-clinical trials have been underway since December 2015.[5]
See also [ ]
Adrafinil
Armodafinil
CE-123
CRL-40,941
Fluorenol
References [ ]
^ CA 1199916 , Lafon L, "Benzhydrylsulfinylacetamide derivatives", published 28 January 1986
^ Cao J, Prisinzano TE, Okunola OM, Kopajtic T, Shook M, Katz JL, Newman AH (October 2010). "Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues" . ACS Medicinal Chemistry Letters . 2 (1): 48–52. doi :10.1021/ml1002025 . PMC 3041981 . PMID 21344069 .
^ US 20130295196 , Konofal E, "Lauflumide and the enantiomers thereof, method for preparing same and therapeutic uses thereof", published 7 November 2013
^ Louis Lafon (18 December 1984). "Patent US 4489095 A - Halogenobenzhydrylsulfinylacetohydroxamic acids" . Retrieved 25 July 2015 .
^ "Pipeline" . NLS Pharmaceuticals .
Stimulants
Adamantanes
Adapromine
Amantadine
Bromantane
Memantine
Rimantadine
Adenosine antagonists Alkylamines
Cyclopentamine
Cypenamine
Cyprodenate
Heptaminol
Isometheptene
Levopropylhexedrine
Methylhexaneamine
Octodrine
Propylhexedrine
Tuaminoheptane
Ampakines Arylcyclohexylamines Benzazepines
6-Br-APB
SKF-77434
SKF-81297
SKF-82958
Cathinones Cholinergics Convulsants Eugeroics Oxazolines Phenethylamines Phenylmorpholines Piperazines
2C-B-BZP
3C-PEP
BZP
CM156
DBL-583
GBR-12783
GBR-12935
GBR-13069
GBR-13098
GBR-13119
MeOPP
MBZP
oMPP
Vanoxerine
Piperidines
1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine
2-Benzylpiperidine
2-Methyl-3-phenylpiperidine
3,4-Dichloromethylphenidate
4-Benzylpiperidine
4-Fluoromethylphenidate
4-Methylmethylphenidate
Desoxypipradrol
Difemetorex
Diphenylpyraline
Ethylnaphthidate
Ethylphenidate
Methylnaphthidate
Isopropylphenidate
JZ-IV-10
Methylphenidate (Dexmethylphenidate )
Nocaine
Phacetoperane
Pipradrol
Propylphenidate
SCH-5472
Pyrrolidines Racetams
Oxiracetam
Phenylpiracetam
Phenylpiracetam hydrazide
Tropanes Tryptamines Others ATC code : N06B
D1 -like
Agonists
Ergolines : Cabergoline
CY-208,243
Dihydroergocryptine
Lisuride
Pergolide
Terguride
Phenethylamines :
Deoxyepinephrine (N-methyldopamine, epinine)
Dopexamine
Etilevodopa
Ibopamine
L -DOPA (levodopa)
Melevodopa
L -Phenylalanine
L -Tyrosine
Others : A-68930
Apomorphine
Nuciferine
PF-6649751
Propylnorapomorphine
Rotigotine
SKF-89,145
Stepholidine
Tavapadon
Tetrahydropalmatine
PAMs Antagonists
Typical antipsychotics : Butaclamol
Chlorpromazine
Chlorprothixene
Flupentixol (flupenthixol) (+melitracen )
Fluphenazine
Loxapine
Perphenazine (+amitriptyline )
Thioridazine
Thiothixene
Trifluoperazine (+tranylcypromine )
Zuclopenthixol
Atypical antipsychotics : Asenapine
Clorotepine
Clotiapine
Clozapine
DHA-clozapine
Fluperlapine
Iloperidone
Norclozapine
Olanzapine (+fluoxetine )
Paliperidone
Quetiapine
Risperidone
Zicronapine
Ziprasidone
Zotepine
Others :
Ecopipam
EEDQ
Metitepine (methiothepin)
Perlapine
SCH-23390
D2 -like
Agonists
Adamantanes : Amantadine
Memantine
Rimantadine
Aminotetralins : 5-OH-DPAT
7-OH-DPAT
8-OH-PBZI
Rotigotine
UH-232
Ergolines : Bromocriptine
Cabergoline
Chanoclavine
Dihydroergocryptine
Epicriptine
Ergocornine
Lergotrile
Lisuride
LSD
Pergolide
Terguride
Phenethylamines : Deoxyepinephrine (N-methyldopamine, epinine)
Dopexamine
Etilevodopa
Ibopamine
L -DOPA (levodopa)
L -Phenylalanine
L -Tyrosine
Melevodopa
Atypical antipsychotics : Alentemol (U-66444B)
Aripiprazole (+sertraline )
Aripiprazole lauroxil
Bifeprunox
Brexpiprazole
Brilaroxazine
Cariprazine
F-15063
Lumateperone
Norclozapine
Others : 3-PPP
A-412997
ABT-670
ABT-724
Adrafinil
Aplindore
Apomorphine
Arketamine
Armodafinil
BP-897
Captodiame
CP-226,269
Dizocilpine
Esketamine
Flibanserin
Ketamine
Mesulergine
Modafinil
OSU-6162
Pardoprunox
PD-128,907
PD-168,077
PF-219,061
PF-592,379
Phencyclidine
Piribedil
Pramipexole
Preclamol
Propylnorapomorphine
Pukateine
Quinagolide
Quinelorane
Quinpirole
RDS-127
Ro10-5824
Ropinirole
Roxindole
Salvinorin A
SKF-83,959
Sumanirole
Talipexole
Umespirone
WAY-100,635
Antagonists
Antiemetics/gastroprokinetics/sedatives : Aceprometazine
AS-8112
Alimemazine
Alizapride
Benzquinamide
Bromopride
Clebopride
Deudomperidone
Domperidone
Eticlopride
Hydroxyzine
Itopride
Metoclopramide
Metopimazine
Promethazine
Thiethylperazine
Trimethobenzamide
Antidepressants : Amoxapine
Nefazodone
Opipramol
Propiomazine
Trimipramine
Others : 3-PPP
Azapride
Bromerguride
Bromocriptine
Buspirone
Desmethoxyfallypride
EEDQ
F-15063
Fallypride
Fananserin
Fenfluramine
Iodobenzamide
L-741,626
L-745,870
Levofenfluramine
Metergoline
Metitepine (methiothepin)
N-Methylspiperone
Nafadotride
Nuciferine
PNU-99,194
Pridopidine
Raclopride
Sarizotan
SB-277,011-A
Sonepiprazole
Spiroxatrine
Stepholidine
Terguride
Tetrahydropalmatine
Tiapride
UH-232
Yohimbine
See also: Receptor/signaling modulators
Adrenergics
Serotonergics
Monoamine reuptake inhibitors
Monoamine releasing agents
Monoamine metabolism modulators
Monoamine neurotoxins