2-MDP
3-amino-2-methyl-1,1-di(phenyl)propan-1-ol
CAS Number PubChem CID ChemSpider CompTox Dashboard (EPA ) Formula C 16 H 19 N O Molar mass 241.334 g·mol−1 3D model (JSmol )
OC(c1ccccc1)(c2ccccc2)C(C)CN
InChI=1S/C16H19NO/c1-13(12-17)16(18,14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,13,18H,12,17H2,1H3
Y Key:XGYCHIPEPHYUIH-UHFFFAOYSA-N
Y
N Y (what is this?)
2-MDP (U-23807A ) is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. The levo or (-) isomer is the active form of the drug.[1] [2] It also has stimulant effects, having only around one third the potency of amphetamine by weight, but with a long duration of action, lasting more than 24 hours from a single oral dose.[3]
References [ ]
^ Tang AH, Cangelosi AA, Code RA, Franklin SR (February 1984). "Phencyclidine-like behavioral effects of 2-methyl-3,3-diphenyl-3-propanolamine (2-MDP)". Pharmacology, Biochemistry, and Behavior . 20 (2): 209–13. doi :10.1016/0091-3057(84)90244-2 . PMID 6718449 .
^ Blake JC, Davies SN, Church J, Martin D, Lodge D (January 1986). "2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) selectively antagonises N-methyl-aspartate (NMA)". Pharmacology, Biochemistry, and Behavior . 24 (1): 23–5. doi :10.1016/0091-3057(86)90038-9 . PMID 3511477 .
^ Biel JH (January 1967). Cain CK (ed.). "Antidepressants, Stimulants, Hallucinogens". Annual Reports in Medicinal Chemistry . Academic Press. 2 : 11–23, 18.
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ATC code : N06B
AMPAR
Antagonists:
Becampanel
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CNQX
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; Positive allosteric modulators: Cyclothiazide
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Isoflurane
Antagonists:
CNQX
Dasolampanel
DNQX
Kaitocephalin
Kynurenic acid
Licostinel (ACEA-1021)
NBQX
NS102
Selurampanel
Tezampanel
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UBP-302 ; Negative allosteric modulators: Barbiturates (e.g., pentobarbital , sodium thiopental )
Enflurane
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Evans blue
Pregnenolone sulfate
NMDAR
See also: Receptor/signaling modulators
Metabotropic glutamate receptor modulators
Glutamate metabolism/transport modulators