For other uses, see Maxair (disambiguation) .
Pirbuterol Trade names Maxair AHFS /Drugs.com Consumer Drug Information MedlinePlus a601096 Pregnancy category Routes of administration Inhalational (MDI ) ATC code Legal status
AU : S4 (Prescription only)
US : ℞-only
(RS )-6-[2-(tert -butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)pyridin-3-ol
CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) Formula C 12 H 20 N 2 O 3 Molar mass 240.303 g·mol−1 3D model (JSmol ) Chirality Racemic mixture
Oc1ccc(nc1CO)C(O)CNC(C)(C)C
InChI=1S/C12H20N2O3/c1-12(2,3)13-6-11(17)8-4-5-10(16)9(7-15)14-8/h4-5,11,13,15-17H,6-7H2,1-3H3
Y Key:VQDBNKDJNJQRDG-UHFFFAOYSA-N
Y
N Y (what is this?)
Pirbuterol (trade name Maxair ) is a short-acting β2 adrenoreceptor agonist with bronchodilating action used in the treatment of asthma , available (as pirbuterol acetate) as a breath-activated metered-dose inhaler .
It was patented in 1971 and came into medical use in 1983.[1]
Medical use [ ]
Pirbuterol is used in asthma for reversal of acute bronchospasm , and also as a maintenance medication to prevent future attacks. It should be used in patients 12 years of age and older with or without concurrent theophylline and/or inhaled corticosteroid .[2] [3]
Mode of action [ ]
Further information: Beta2-adrenergic agonist
Pharmacokinetics [ ]
After inhalation of doses up to 800 μ g (twice the maximum recommended dose) systemic blood levels of pirbuterol are below the limit of assay sensitivity (2–5 ng/ml). A mean of 51% of the dose is recovered in urine as pirbuterol plus its sulfate conjugate following administration by aerosol. Pirbuterol is not metabolized by catechol-O -methyltransferase . The plasma half-life measured after oral administration is about two hours.[2]
Adverse effects [ ]
Further information: Beta2-adrenergic agonist
References [ ]
External links [ ]
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