TRPM4-IN-5

TRPM4-IN-5
Identifiers
	IUPAC name 4-chloro-2-{[2-(2-chlorophenoxy)acetyl]amino}benzoic acid;
CAS Number	351424-20-9;
PubChem CID	2264067;
ChemSpider	1692848;
Chemical and physical data
Formula	C15H11Cl2NO4
Molar mass	340.16 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl;
	InChI InChI=1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21); Key:CVQCJPCMPGKEDH-UHFFFAOYSA-N;

TRPM4-IN-5 is a drug which acts as a moderately potent but highly selective blocker of the TRPM4 ion channel, with an IC₅₀ of 1.5μM.^[1] It is protective against glutamate mediated neuronal excitotoxicity.^[2]

References[]

^ Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, et al. (June 2018). "Identification of potent and selective small molecule inhibitors of the cation channel TRPM4". British Journal of Pharmacology. 175 (12): 2504–2519. doi:10.1111/bph.14220. PMC 6002741. PMID 29579323.
^ Bianchi B, Smith PA, Abriel H (July 2018). "The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration". Molecular Brain. 11 (1): 41. doi:10.1186/s13041-018-0385-4. PMC 6042389. PMID 29996905.

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[Ozhathil_2018-1] Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, et al. (June 2018). "Identification of potent and selective small molecule inhibitors of the cation channel TRPM4". British Journal of Pharmacology. 175 (12): 2504–2519. doi:10.1111/bph.14220. PMC 6002741. PMID 29579323.

[Bianchi_2018-2] Bianchi B, Smith PA, Abriel H (July 2018). "The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration". Molecular Brain. 11 (1): 41. doi:10.1186/s13041-018-0385-4. PMC 6042389. PMID 29996905.

[1]

[2]

Identifiers

IUPAC name 4-chloro-2-{[2-(2-chlorophenoxy)acetyl]amino}benzoic acid
CAS Number	351424-20-9
PubChem CID	2264067
ChemSpider	1692848
Chemical and physical data
Formula	C₁₅H₁₁Cl₂NO₄
Molar mass	340.16 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C(=C1)OCC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O)Cl
InChI InChI=1S/C15H11Cl2NO4/c16-9-5-6-10(15(20)21)12(7-9)18-14(19)8-22-13-4-2-1-3-11(13)17/h1-7H,8H2,(H,18,19)(H,20,21) Key:CVQCJPCMPGKEDH-UHFFFAOYSA-N