TRPM4

TRPM4
Identifiers
Aliases	TRPM4, PFHB1B, TRPM4B, LTrpC4, htransient receptor potential cation channel subfamily M member 4, EKVP6
External IDs	OMIM: 606936 MGI: 1915917 HomoloGene: 23033 GeneCards: TRPM4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,211,836 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,333,780 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • calcium channel activity; • calmodulin binding; • ion channel activity; • ATP binding; • sodium channel activity; • calcium activated cation channel activity; • calcium ion binding; • metal ion binding;
Cellular component	• integral component of membrane; • Golgi apparatus; • membrane; • plasma membrane; • nucleoplasm; • endoplasmic reticulum; • cytosol; • neuronal cell body; • sodium channel complex; • spanning component of plasma membrane; • spanning component of membrane;
Biological process	• adaptive immune response; • vasoconstriction; • immune system process; • positive regulation of canonical Wnt signaling pathway; • regulation of membrane potential; • cation transport; • ion transport; • protein sumoylation; • dendritic cell chemotaxis; • regulation of T cell cytokine production; • cardiac conduction; • positive regulation of cell population proliferation; • calcium ion transport; • negative regulation of bone mineralization; • positive regulation of atrial cardiac muscle cell action potential; • positive regulation of heart rate; • transmembrane transport; • positive regulation of adipose tissue development; • positive regulation of cytosolic calcium ion concentration; • calcium ion transmembrane transport; • positive regulation of fat cell differentiation; • positive regulation of insulin secretion involved in cellular response to glucose stimulus; • negative regulation of osteoblast differentiation; • positive regulation of vasoconstriction; • positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization; • ion transmembrane transport; • calcium-mediated signaling; • membrane depolarization during AV node cell action potential; • membrane depolarization during Purkinje myocyte cell action potential; • membrane depolarization during bundle of His cell action potential; • regulation of heart rate by cardiac conduction; • sodium ion import across plasma membrane; • regulation of ventricular cardiac muscle cell action potential; • protein homotetramerization; • cellular response to ATP; • inorganic cation transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	54795
	68667
	ENSG00000130529
	ENSMUSG00000038260
	Q8TD43
	Q7TN37
NM_001195227; NM_017636; NM_001321281; NM_001321282; NM_001321283;
	NM_001321285
	NM_175130
NP_001182156; NP_001308210; NP_001308211; NP_001308212; NP_001308214;
	NP_060106
	NP_780339
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.^[5]^[6]

TRPM4 Channel Blocker[]

9-Phenanthrol
TRPM4-IN-5

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130529 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038260 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu XZ, Moebius F, Gill DL, Montell C (September 2001). "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi:10.1073/pnas.191360198. PMC 58528. PMID 11535825.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

External links[]

TRPM4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130529 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038260 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11535825-5] Xu XZ, Moebius F, Gill DL, Montell C (September 2001). "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi:10.1073/pnas.191360198. PMC 58528. PMID 11535825.

[pmid16382100-6] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

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TRPM4

Contents

TRPM4 Channel Blocker[]

See also[]

References[]

Further reading[]

External links[]