KCNK17 Identifiers Aliases KCNK17 , K2p17.1, TALK-2, TALK2, TASK-4, TASK4, potassium two pore domain channel subfamily K member 17External IDs OMIM : 607370 HomoloGene : 88928 GeneCards : KCNK17 Gene location (Human ) Chr. Chromosome 6 (human) [1] Band 6p21.2 Start 39,299,001 bp [1] End 39,314,461 bp [1]
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 6: 39.3 – 39.31 Mb n/a PubMed search[2] n/a Wikidata
Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene .[3] [4]
This gene encodes K2P 17.1 , one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel, primarily expressed in the pancreas, is activated at alkaline pH.[4]
See also [ ]
Tandem pore domain potassium channel
References [ ]
Further reading [ ]
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions" . Genome Res . 14 (9): 1711–8. doi :10.1101/gr.2435604 . PMC 515316 . PMID 15342556 .
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 . PMID 14574404 .
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 . PMID 12975309 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Girard C, Duprat F, Terrenoire C, et al. (2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem. Biophys. Res. Commun . 282 (1): 249–56. doi :10.1006/bbrc.2001.4562 . PMID 11263999 .
Decher N, Maier M, Dittrich W, et al. (2001). "Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family" . FEBS Lett . 492 (1–2): 84–9. doi :10.1016/S0014-5793(01)02222-0 . PMID 11248242 . S2CID 23620127 .
External links [ ]
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
Ligand-gated Voltage-gated
α2 δ-subunits
β-subunits
γ-subunits
Na+ : Sodium channel
Constitutively active
Epithelial sodium channel
Proton -gated
Amiloride-sensitive cation channel
Voltage-gated
Nav α
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
7A
Nav β
K+ : Potassium channel
Calcium-activated Inward-rectifier Tandem pore domain Voltage-gated
Miscellaneous
Cl− : Chloride channel
Calcium-activated chloride channels
Anoctamin
Bestrophin
Chloride Channel Accessory
CFTR
CLCN
CLIC
CLNS
H+ : Proton channel M+ : CNG cation channel M+ : TRP cation channel H2 O (+ solutes ): Porin Cytoplasm : Gap junction
see also disorders