From Wikipedia, the free encyclopedia
KCNA6 Identifiers Aliases KCNA6 , HBK2, KV1.6, PPP1R96, potassium voltage-gated channel subfamily A member 6External IDs OMIM : 176257 MGI : 96663 HomoloGene : 1684 GeneCards : KCNA6 Gene location (Human ) Chr. Chromosome 12 (human) [1] Band 12p13.32 Start 4,809,176 bp [1] End 4,813,412 bp [1]
Gene location (Mouse ) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 61.72 cM Start 126,685,292 bp [2] End 126,717,637 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 12: 4.81 – 4.81 Mb Chr 6: 126.69 – 126.72 Mb PubMed search[3] [4] Wikidata
Potassium voltage-gated channel subfamily A member 6 also known as Kv 1.6 is a protein that in humans is encoded by the KCNA6 gene .[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000151079 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038077 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels" (PDF) . Pharmacol Rev . 57 (4): 473–508. doi :10.1124/pr.57.4.10 . PMID 16382104 . S2CID 219195192 .
Further reading [ ]
Albrecht B, Weber K, Pongs O (1995). "Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13". Recept. Channels . 3 (3): 213–20. PMID 8821794 .
Tan KM, Lennon VA, Klein CJ, et al. (2008). "Clinical spectrum of voltage-gated potassium channel autoimmunity". Neurology . 70 (20): 1883–90. doi :10.1212/01.wnl.0000312275.04260.a0 . PMID 18474843 . S2CID 34815377 .
Grupe A, Schröter KH, Ruppersberg JP, et al. (1990). "Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family" . EMBO J . 9 (6): 1749–56. doi :10.1002/j.1460-2075.1990.tb08299.x . PMC 551878 . PMID 2347305 .
Yusifov T, Savalli N, Gandhi CS, et al. (2008). "The RCK2 domain of the human BKCa channel is a calcium sensor" . Proc. Natl. Acad. Sci. U.S.A . 105 (1): 376–81. Bibcode :2008PNAS..105..376Y . doi :10.1073/pnas.0705261105 . PMC 2224220 . PMID 18162557 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
External links [ ]
Ligand-gated Voltage-gated
α2 δ-subunits
β-subunits
γ-subunits
Na+ : Sodium channel
Constitutively active
Epithelial sodium channel
Proton -gated
Amiloride-sensitive cation channel
Voltage-gated
Nav α
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
7A
Nav β
K+ : Potassium channel
Calcium-activated Inward-rectifier Tandem pore domain Voltage-gated
Miscellaneous
Cl− : Chloride channel
Calcium-activated chloride channels
Anoctamin
Bestrophin
Chloride Channel Accessory
CFTR
CLCN
CLIC
CLNS
H+ : Proton channel M+ : CNG cation channel M+ : TRP cation channel H2 O (+ solutes ): Porin Cytoplasm : Gap junction
see also disorders
Categories :
Genes on human chromosome 12 Ion channels Membrane protein stubs