CLCC1 Identifiers Aliases CLCC1 , MCLC, chloride channel CLIC like 1External IDs OMIM : 617539 MGI : 2385186 HomoloGene : 9032 GeneCards : CLCC1 Gene location (Human ) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 108,929,508 bp [1] End 108,963,457 bp [1]
Gene location (Mouse ) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 108,561,229 bp [2] End 108,586,156 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 1: 108.93 – 108.96 Mb Chr 3: 108.56 – 108.59 Mb PubMed search[3] [4] Wikidata
Chloride channel CLIC-like 1 also known as CLCC1 is a human gene .[5] [6]
The protein encoded by this gene is a chloride channel which is related in sequence to the S. cerevisiae MID-1 stretch-activated channel. CLCC1 is located in the membranes of intracellular compartments including endoplasmic reticulum and the Golgi apparatus . It is highly expressed in the testis and moderately in the spleen, liver, kidney, heart, brain, and lung.[6]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000121940 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027884 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 5 (5): 277–86. doi :10.1093/dnares/5.5.277 . PMID 9872452 .
^ a b Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I (June 2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus" . J. Biol. Chem . 276 (23): 20413–8. doi :10.1074/jbc.M100366200 . PMID 11279057 .
Further reading [ ]
Nagase T, Ishikawa K, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 5 (5): 277–86. doi :10.1093/dnares/5.5.277 . PMID 9872452 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 . PMID 16344560 .
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions" . Genome Res . 14 (9): 1711–8. doi :10.1101/gr.2435604 . PMC 515316 . PMID 15342556 .
Nagasawa M, Kanzaki M, Iino Y, et al. (2001). "Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus" . J. Biol. Chem . 276 (23): 20413–8. doi :10.1074/jbc.M100366200 . PMID 11279057 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
External links [ ]
CLCC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CLCC1 genome location and CLCC1 gene details page in the UCSC Genome Browser .
Ligand-gated Voltage-gated
α2 δ-subunits
β-subunits
γ-subunits
Na+ : Sodium channel
Constitutively active
Epithelial sodium channel
Proton -gated
Amiloride-sensitive cation channel
Voltage-gated
Nav α
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
7A
Nav β
K+ : Potassium channel
Calcium-activated Inward-rectifier Tandem pore domain Voltage-gated
Miscellaneous
Cl− : Chloride channel
Calcium-activated chloride channels
Anoctamin
Bestrophin
Chloride Channel Accessory
CFTR
CLCN
CLIC
CLNS
H+ : Proton channel M+ : CNG cation channel M+ : TRP cation channel H2 O (+ solutes ): Porin Cytoplasm : Gap junction
see also disorders