KCNK7 Identifiers Aliases KCNK7 , K2p7.1, TWIK3, potassium two pore domain channel subfamily K member 7External IDs OMIM : 603940 MGI : 1341841 HomoloGene : 43131 GeneCards : KCNK7 Gene location (Human ) Chr. Chromosome 11 (human) [1] Band 11q13.1 Start 65,592,836 bp [1] End 65,595,996 bp [1]
Gene location (Mouse ) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,754,395 bp [2] End 5,757,137 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 11: 65.59 – 65.6 Mb Chr 19: 5.75 – 5.76 Mb PubMed search[3] [4] Wikidata
Potassium channel, subfamily K, member 7 , also known as KCNK7 or K2P 7.1 is a protein which is encoded in humans by the KCNK7 gene . K2P 7.1 is a potassium channel containing two pore-forming P domains.[5] [6] [7] Multiple transcript variants encoding different isoforms have been found for this gene.[8]
Function [ ]
This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains . The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.[8]
See also [ ]
Tandem pore domain potassium channel
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000173338 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024936 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure" . J. Biol. Chem . 274 (17): 11751–60. doi :10.1074/jbc.274.17.11751 . PMID 10206991 .
^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits" . Nat. Rev. Neurosci . 2 (3): 175–84. doi :10.1038/35058574 . PMID 11256078 . S2CID 9682396 .
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels" . Pharmacol. Rev . 57 (4): 527–40. doi :10.1124/pr.57.4.12 . PMID 16382106 . S2CID 7356601 .
^ a b "Entrez Gene: potassium channel" .
Further reading [ ]
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits" . Nat. Rev. Neurosci . 2 (3): 175–84. doi :10.1038/35058574 . PMID 11256078 . S2CID 9682396 .
Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure" . J. Biol. Chem . 274 (17): 11751–60. doi :10.1074/jbc.274.17.11751 . PMID 10206991 .
Medhurst AD, Rennie G, Chapman CG, et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery". Brain Res. Mol. Brain Res . 86 (1–2): 101–14. doi :10.1016/S0169-328X(00)00263-1 . PMID 11165377 .
External links [ ]
KCNK7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
KCNK7 human gene location in the UCSC Genome Browser .
KCNK7 human gene details in the UCSC Genome Browser .
Ligand-gated Voltage-gated
α2 δ-subunits
β-subunits
γ-subunits
Na+ : Sodium channel
Constitutively active
Epithelial sodium channel
Proton -gated
Amiloride-sensitive cation channel
Voltage-gated
Nav α
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
7A
Nav β
K+ : Potassium channel
Calcium-activated Inward-rectifier Tandem pore domain Voltage-gated
Miscellaneous
Cl− : Chloride channel
Calcium-activated chloride channels
Anoctamin
Bestrophin
Chloride Channel Accessory
CFTR
CLCN
CLIC
CLNS
H+ : Proton channel M+ : CNG cation channel M+ : TRP cation channel H2 O (+ solutes ): Porin Cytoplasm : Gap junction
see also disorders