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KCNK13 Identifiers Aliases KCNK13 External IDs OMIM : 607367 MGI : 2384976 HomoloGene : 69351 GeneCards : KCNK13 Gene location (Human ) Chr. Chromosome 14 (human) [1] Band 14q32.11 Start 90,061,994 bp [1] End 90,185,853 bp [1]
Gene location (Mouse ) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 99,930,758 bp [2] End 100,028,941 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 14: 90.06 – 90.19 Mb Chr 12: 99.93 – 100.03 Mb PubMed search[3] [4] Wikidata
Potassium channel, subfamily K, member 13 , also known as KCNK13 is a human gene . The protein encoded by this gene, K2P 13.1 is a potassium channel containing two pore-forming P domains.[5] [6]
See also [ ] Tandem pore domain potassium channel References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000152315 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045404 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels" . J. Biol. Chem . 276 (10): 7302–11. doi :10.1074/jbc.M008985200 PMID 11060316 . ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels" . Pharmacol. Rev . 57 (4): 527–40. doi :10.1124/pr.57.4.12 . PMID 16382106 . S2CID 7356601 .
Further reading [ ]
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Fearon IM, Campanucci VA, Brown ST, et al. (2006). "Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells" . Adv. Exp. Med. Biol . ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 580 : 203–8, discussion 351–9 . doi :10.1007/0-387-31311-7_31 . ISBN 978-0-387-31310-8 PMID 16683720 . Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits" . Nat. Rev. Neurosci . 2 (3): 175–84. doi :10.1038/35058574 . PMID 11256078 . S2CID 9682396 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Theilig F, Goranova I, Hirsch JR, et al. (2008). "Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney" . Cell. Physiol. Biochem . 21 (1–3): 63–74. doi :10.1159/000113748 PMID 18209473 . Gierten J, Ficker E, Bloehs R, et al. (2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein" . Br. J. Pharmacol . 154 (8): 1680–90. doi :10.1038/bjp.2008.213 . PMC 2518462 PMID 18516069 .
External links [ ]
Ligand-gated Voltage-gated
α2 δ-subunits
β-subunits
γ-subunits
Na+ : Sodium channel
Constitutively active
Epithelial sodium channel
Proton -gated
Amiloride-sensitive cation channel
Voltage-gated
Nav α
1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Nav β
K+ : Potassium channel
Calcium-activated Inward-rectifier Tandem pore domain Voltage-gated
Miscellaneous
Cl− :Chloride channel
Calcium-activated chloride channels
Anoctamin
Bestrophin
Chloride Channel Accessory
CFTR CLCN
CLIC
CLNS
H+ :Proton channel M+ :CNG cation channel M+ :TRP cation channel H2 O (+ solutes ):Porin Cytoplasm :Gap junction
see also disorders
Categories :
Genes on human chromosome 14 Ion channels Membrane protein stubs
