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KCNG4 Identifiers Aliases KCNG4 , KV6.3, KV6.4, potassium voltage-gated channel modifier subfamily G member 4External IDs OMIM : 607603 MGI : 1913983 HomoloGene : 23553 GeneCards : KCNG4 Gene location (Human ) Chr. Chromosome 16 (human) [1] Band 16q24.1 Start 84,218,657 bp [1] End 84,240,012 bp [1]
Gene location (Mouse ) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 120,350,593 bp [2] End 120,362,419 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 16: 84.22 – 84.24 Mb Chr 8: 120.35 – 120.36 Mb PubMed search[3] [4] Wikidata
Potassium voltage-gated channel subfamily G member 4 is a protein that in humans is encoded by the KCNG4 gene .[5] [6] The protein encoded by this gene is a voltage-gated potassium channel subunit.[6]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000168418 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045246 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (Jun 2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome" . Proc Natl Acad Sci U S A . 99 (12): 7986–91. Bibcode :2002PNAS...99.7986O . doi :10.1073/pnas.122617999 . PMC 123007 . PMID 12060745 .
^ a b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev . 57 (4): 473–508. doi :10.1124/pr.57.4.10 . PMID 16382104 . S2CID 219195192 .
Further reading [ ]
Mederos Y, Schnitzler M, Rinné S, Skrobek L, et al. (2009). "Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4" . J. Biol. Chem . 284 (7): 4695–704. doi :10.1074/jbc.M808786200 . PMID 19074135 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Ottschytsch N, Raes AL, Timmermans JP, Snyders DJ (2005). "Domain analysis of Kv6.3, an electrically silent channel" . J. Physiol . 568 (Pt 3): 737–47. doi :10.1113/jphysiol.2005.090142 . PMC 1464172 . PMID 16096342 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
External links [ ]
Ligand-gated Voltage-gated
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γ-subunits
Na+ : Sodium channel
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Amiloride-sensitive cation channel
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K+ : Potassium channel
Calcium-activated Inward-rectifier Tandem pore domain Voltage-gated
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Cl− : Chloride channel
Calcium-activated chloride channels
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Chloride Channel Accessory
CFTR
CLCN
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H+ : Proton channel M+ : CNG cation channel M+ : TRP cation channel H2 O (+ solutes ): Porin Cytoplasm : Gap junction
see also disorders
Categories :
Genes on human chromosome 16 Ion channels Membrane protein stubs