KCNA7

KCNA7
Identifiers
Aliases	KCNA7, HAK6, KV1.7, potassium voltage-gated channel subfamily A member 7
External IDs	OMIM: 176268 MGI: 96664 HomoloGene: 7791 GeneCards: KCNA7
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,072,699 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,059,187 bp
RNA expression pattern
	Top expressed in
	muscle of leg; ; vastus lateralis muscle; ; deltoid muscle; ; gastrocnemius muscle; ; quadriceps femoris muscle; ; biceps brachii;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel activity; potassium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity; delayed rectifier potassium channel activity;
Cellular component	integral component of membrane; voltage-gated potassium channel complex; plasma membrane; membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; protein homooligomerization; ion transport; transmembrane transport; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	3743
	16495
	ENSG00000104848
	ENSMUSG00000038201
	Q96RP8
	Q17ST2
	NM_031886
	NM_010596
	NP_114092
	NP_034726
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily A member 7 also known as K_v1.7 is a protein that in humans is encoded by the KCNA7 gene.^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit. It may contribute to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104848 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038201 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
^ Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410.

External links[]

Kv1.7+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
KCNA7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104848 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038201 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382104-5] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[oudit-6] Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410.

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KCNA7

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