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KCNA10 Available structures PDB Ortholog search: PDBe RCSB
Identifiers Aliases KCNA10 , Kcn1, Kv1.8, potassium voltage-gated channel subfamily A member 10External IDs OMIM : 602420 MGI : 3037820 HomoloGene : 4054 GeneCards : KCNA10 Gene location (Human ) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 110,517,217 bp [1] End 110,519,175 bp [1]
Gene location (Mouse ) Chr. Chromosome 3 (mouse)[2] Band 3 F2.3|3 46.64 cM Start 107,090,372 bp [2] End 107,103,037 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 1: 110.52 – 110.52 Mb Chr 3: 107.09 – 107.1 Mb PubMed search[3] [4] Wikidata
Potassium voltage-gated channel subfamily A member 10 also known as Kv 1.8 is a protein that in humans is encoded by the KCNA10 gene .[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000143105 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042861 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev . 57 (4): 473–508. doi :10.1124/pr.57.4.10 . PMID 16382104 . S2CID 219195192 .
Further reading [ ]
Landes GM, Curran ME, Keating MT (1995). "Molecular characterization and refined genomic localization of three human potassium ion channel genes". Cytogenet. Cell Genet . 70 (3–4): 280–4. doi :10.1159/000134052 . PMID 7789190 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Tian S, Liu W, Wu Y, et al. (2002). "Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit". Am. J. Physiol. Renal Physiol . 283 (1): F142–9. doi :10.1152/ajprenal.00258.2001 . PMID 12060596 .
Orias M, Bray-Ward P, Curran ME, et al. (1997). "Genomic localization of the human gene for KCNA10, a cGMP-activated K channel". Genomics . 42 (1): 33–7. doi :10.1006/geno.1997.4712 . PMID 9177773 .
Lang R, Lee G, Liu W, et al. (2000). "KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels". Am. J. Physiol. Renal Physiol . 278 (6): F1013–21. doi :10.1152/ajprenal.2000.278.6.F1013 . PMID 10836990 .
Yao X, Tian S, Chan HY, et al. (2002). "Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule" . J. Am. Soc. Nephrol . 13 (12): 2831–9. doi :10.1097/01.ASN.0000036866.37886.C5 . PMID 12444201 .
External links [ ]
Ligand-gated Voltage-gated
α2 δ-subunits
β-subunits
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Na+ : Sodium channel
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Epithelial sodium channel
Proton -gated
Amiloride-sensitive cation channel
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K+ : Potassium channel
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Cl− : Chloride channel
Calcium-activated chloride channels
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H+ : Proton channel M+ : CNG cation channel M+ : TRP cation channel H2 O (+ solutes ): Porin Cytoplasm : Gap junction
see also disorders
Categories :
Genes on human chromosome 1 Ion channels Membrane protein stubs