KCNK12 Identifiers Aliases KCNK12 External IDs OMIM : 607366 MGI : 2684043 HomoloGene : 11107 GeneCards : KCNK12 Gene location (Human ) Chr. Chromosome 2 (human) [1] Band 2p16.3 Start 47,509,290 bp [1] End 47,570,985 bp [1]
Gene location (Mouse ) Chr. Chromosome 17 (mouse)[2] Band 17|17 E4 Start 88,053,229 bp [2] End 88,105,422 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 2: 47.51 – 47.57 Mb Chr 17: 88.05 – 88.11 Mb PubMed search[3] [4] Wikidata
Potassium channel, subfamily K, member 12 , also known as KCNK12 is a human gene . The protein encoded by this gene, K2P 12.1, is a potassium channel containing two pore-forming P domains.[5]
See also [ ] Tandem pore domain potassium channel References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000184261 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050138 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Rajan S, Wischmeyer E, Karschin C, Preisig-Müller R, Grzeschik KH, Daut J, Karschin A, Derst C (March 2001). "THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels" . J. Biol. Chem . 276 (10): 7302–11. doi :10.1074/jbc.M008985200 PMID 11060316 .
Further reading [ ]
Girard C, Duprat F, Terrenoire C, et al. (2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem. Biophys. Res. Commun . 282 (1): 249–56. doi :10.1006/bbrc.2001.4562 . PMID 11263999 . Nyholt DR, LaForge KS, Kallela M, et al. (2008). "A high-density association screen of 155 ion transport genes for involvement with common migraine" . Hum. Mol. Genet . 17 (21): 3318–31. doi :10.1093/hmg/ddn227 . PMC 2566523 PMID 18676988 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits" . Nat. Rev. Neurosci . 2 (3): 175–84. doi :10.1038/35058574 . PMID 11256078 . S2CID 9682396 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Theilig F, Goranova I, Hirsch JR, et al. (2008). "Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney" . Cell. Physiol. Biochem . 21 (1–3): 63–74. doi :10.1159/000113748 PMID 18209473 .
External links [ ]
Ligand-gated Voltage-gated
α2 δ-subunits
β-subunits
γ-subunits
Na+ : Sodium channel
Constitutively active
Epithelial sodium channel
Proton -gated
Amiloride-sensitive cation channel
Voltage-gated
Nav α
1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Nav β
K+ : Potassium channel
Calcium-activated Inward-rectifier Tandem pore domain Voltage-gated
Miscellaneous
Cl− :Chloride channel
Calcium-activated chloride channels
Anoctamin
Bestrophin
Chloride Channel Accessory
CFTR CLCN
CLIC
CLNS
H+ :Proton channel M+ :CNG cation channel M+ :TRP cation channel H2 O (+ solutes ):Porin Cytoplasm :Gap junction
see also disorders
