KCNJ8

KCNJ8
Identifiers
Aliases	KCNJ8, KIR6.1, uKATP-1, potassium voltage-gated channel subfamily J member 8, potassium inwardly rectifying channel subfamily J member 8
External IDs	OMIM: 600935 MGI: 1100508 HomoloGene: 3654 GeneCards: KCNJ8
Gene location (Human)
Chr.	Chromosome 12 (human)
End	21,775,600 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	142,571,614 bp
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• voltage-gated ion channel activity; • ATP binding; • inward rectifier potassium channel activity; • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; • ATP-activated inward rectifier potassium channel activity; • sulfonylurea receptor binding;
Cellular component	• integral component of membrane; • membrane; • intracellular membrane-bounded organelle; • voltage-gated potassium channel complex; • plasma membrane; • myofibril; • mitochondrion; • inward rectifying potassium channel; • sarcolemma;
Biological process	• response to exogenous dsRNA; • kidney development; • regulation of ion transmembrane transport; • ion transport; • heart development; • response to lipopolysaccharide; • defense response to virus; • potassium ion transport; • membrane repolarization during ventricular cardiac muscle cell action potential; • potassium ion import across plasma membrane; • ion transmembrane transport; • potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	3764
	16523
	ENSG00000121361
	ENSMUSG00000030247
	Q15842
	P97794
	NM_004982
	NM_008428; NM_001330363; NM_001330366
	NP_004973
	NP_001317292; NP_001317295; NP_032454
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the K_ir6.1 protein.^[5] A mutation in KCNJ8 has been associated with cardiac arrest in the early repolarization syndrome.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir6.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir6.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.^[5]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121361 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030247 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8".

Further reading[]

Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–526. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
Inagaki N, Tsuura Y, Namba N, et al. (1995). "Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart". J. Biol. Chem. 270 (11): 5691–5694. doi:10.1074/jbc.270.11.5691. PMID 7890693.
Inagaki N, Inazawa J, Seino S (1996). "cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8)". Genomics. 30 (1): 102–104. doi:10.1006/geno.1995.0018. PMID 8595887.
Suzuki M, Kotake K, Fujikura K, et al. (1998). "Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria". Biochem. Biophys. Res. Commun. 241 (3): 693–697. doi:10.1006/bbrc.1997.7891. PMID 9434770.
Erginel-Unaltuna N, Yang WP, Blanar MA (1998). "Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel". Gene. 211 (1): 71–78. doi:10.1016/S0378-1119(98)00086-9. PMID 9573340.
Surah-Narwal S, Xu SZ, McHugh D, et al. (1999). "Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A". Br. J. Pharmacol. 128 (3): 667–672. doi:10.1038/sj.bjp.0702862. PMC 1571700. PMID 10516647.
Tucker SJ, Ashcroft FM (1999). "Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2". J. Biol. Chem. 274 (47): 33393–33397. doi:10.1074/jbc.274.47.33393. PMID 10559219.
Kono Y, Horie M, Takano M, et al. (2001). "The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A". Pflügers Arch. 440 (5): 692–698. doi:10.1007/s004240000315. PMID 11007308. S2CID 31022216.
Cui Y, Giblin JP, Clapp LH, Tinker A (2001). "A mechanism for ATP-sensitive potassium channel diversity: Functional coassembly of two pore-forming subunits". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 729–734. doi:10.1073/pnas.011370498. PMC 14656. PMID 11136227.
Liu Y, Ren G, O'Rourke B, et al. (2001). "Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels". Mol. Pharmacol. 59 (2): 225–30. doi:10.1124/mol.59.2.225. PMID 11160857.
Giblin JP, Cui Y, Clapp LH, Tinker A (2002). "Assembly limits the pharmacological complexity of ATP-sensitive potassium channels". J. Biol. Chem. 277 (16): 13717–13723. doi:10.1074/jbc.M112209200. PMID 11825905.
Vanoye CG, MacGregor GG, Dong K, et al. (2002). "The carboxyl termini of K(ATP) channels bind nucleotides". J. Biol. Chem. 277 (26): 23260–23270. doi:10.1074/jbc.M112004200. PMID 11956191.
Miki T, Suzuki M, Shibasaki T, et al. (2002). "Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1". Nat. Med. 8 (5): 466–472. doi:10.1038/nm0502-466. PMID 11984590. S2CID 32502965.
Nakamura K, Hirano J, Itazawa S, Kubokawa M (2002). "Protein kinase G activates inwardly rectifying K(+) channel in cultured human proximal tubule cells". Am. J. Physiol. Renal Physiol. 283 (4): F784–91. doi:10.1152/ajprenal.00023.2002. PMID 12217870.
Curley M, Cairns MT, Friel AM, et al. (2003). "Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium". Mol. Hum. Reprod. 8 (10): 941–945. doi:10.1093/molehr/8.10.941. PMID 12356945.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Singh H, Hudman D, Lawrence CL, et al. (2004). "Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes". J. Mol. Cell. Cardiol. 35 (5): 445–459. doi:10.1016/S0022-2828(03)00041-5. hdl:2381/14. PMID 12738227.
Insuk SO, Chae MR, Choi JW, et al. (2003). "Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells". Int. J. Impot. Res. 15 (4): 258–266. doi:10.1038/sj.ijir.3901013. PMID 12934053.
Emanuele E, Falcone C, Carabela M, et al. (2004). "Absence of Kir6.1/KCNJ8 mutations in Italian patients with abnormal coronary vasomotion". Int. J. Mol. Med. 12 (4): 509–12. doi:10.3892/ijmm.12.4.509. PMID 12964027.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links[]

KCNJ8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000121361 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030247 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8".

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KCNJ8

Contents

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