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Triflubazam
1-methyl-5-phenyl-7-(trifluoromethyl)-1H -1,5-benzodiazepine-2,4(3H ,5H )-dione
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) Formula C 17 H 13 F 3 N 2 O 2 Molar mass 334.298 g·mol−1 3D model (JSmol )
FC(F)(C1=CC(N(C2=CC=CC=C2)C(CC(N3C)=O)=O)=C3C=C1)F
InChI=1S/C17H13F3N2O2/c1-21-13-8-7-11(17(18,19)20)9-14(13)22(16(24)10-15(21)23)12-5-3-2-4-6-12/h2-9H,10H2,1H3
Y Key:DMNPCIKBNDKNTO-UHFFFAOYSA-N
Y
Triflubazam [1] is a drug which is a 1,5-benzodiazepine derivative, related to clobazam .[2] It has sedative and anxiolytic effects, with a long half-life and duration of action.[3] [4] [5]
See also [ ]
Benzodiazepine
Clobazam
CP-1414S
Triflunordazepam
References [ ]
^ US 3660381 , Karl-Heinz Weber KH, Merz H, K Zeile, Giesemann R, Danneberg P, "5-Aryl-1H-1,5-benzodiazepine-2,4-diones", issued 2 May 1972, assigned to CH Boehringer Sohn AG and Co KG
^ Lundbeck Institute (2003). "triflubazam" . psychotropics.dk. Retrieved 17 November 2010 .
^ Itil TM, Akpinar S, Fink M, Polvan N, Huque M, Sungurbey K (March 1976). "Controlled clinical and quantitative EEG studies of triflubazam (ORF 8063) in patients with anxiety syndrome". Current Therapeutic Research, Clinical and Experimental . 19 (3): 307–15. PMID 5248 .
^ Csanalosi I, Pereira-Oran J, Case G, et al. (1977). "Triflubazam (ORF 8063), a new benzodiazepine in anxiety neurosis". Current Therapeutic Research . 22 : 166–171.
^ Nicholson AN, Stone BM, Clarke CH (October 1977). "Effect of the 1,5-benzodiazepines, clobazam and triflubazam, on sleep in man" . British Journal of Clinical Pharmacology . 4 (5): 567–72. doi :10.1111/j.1365-2125.1977.tb00787.x . PMC 1429140 . PMID 20917 .
Benzodiazepines
1,4-Benzodiazepines 1,5-Benzodiazepines 2,3-Benzodiazepines* Triazolobenzodiazepines Imidazobenzodiazepines
Bretazenil
Climazolam
EVT-201
FG-8205
Flumazenil
GL-II-73
Imidazenil
123 I-Iomazenil
L-655,708
Loprazolam
Midazolam
PWZ-029
Remimazolam
Ro15-4513
Ro48-6791
Ro48-8684
Ro4938581
Sarmazenil
SH-053-R-CH3-2′F
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See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators
Categories :
Benzodiazepines GABAA receptor positive allosteric modulators Lactams Trifluoromethyl compounds Sedative stubs Hidden categories:
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