NS-2664
5-furan-3-yl-1-(3-imidazol-1-yl-phenyl)-1H-benzoimidazole
CAS Number PubChem CID ChemSpider Formula C 20 H 14 N 4 O Molar mass 326.359 g·mol−1 3D model (JSmol )
c5occc5-c(cc1nc4)ccc1n4-c2cc(ccc2)-n3cncc3
InChI=1S/C20H14N4O/c1-2-17(23-8-7-21-13-23)11-18(3-1)24-14-22-19-10-15(4-5-20(19)24)16-6-9-25-12-16/h1-14H
N Key:QMKRPSVBKKEAKS-UHFFFAOYSA-N
N
N Y (what is this?)
NS-2664 (LS-193,048 ) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company NeuroSearch . It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABAA receptors , although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.[1]
References [ ]
^ Mirza NR, Nielsen EØ (March 2006). "Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice?". The Journal of Pharmacology and Experimental Therapeutics . 316 (3): 1378–85. doi :10.1124/jpet.105.094474 . PMID 16352707 . S2CID 22700422 .
Anxiolytics (N05B )
5-HT1A R agonists GABAA R PAMs
Benzodiazepines : Adinazolam
Alprazolam
Bromazepam
Camazepam
Chlordiazepoxide
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Lorazepam #
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Prazepam ; Others: Alpidem ‡
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Carisoprodol
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Selank
Tiagabine
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Validolum
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
GABA A receptor positive modulatorsAlcohols
Butanol
Chloralodol
Chlorobutanol (cloretone)
Ethanol (alcohol) (alcoholic drink )
Ethchlorvynol
Isobutanol
Isopropanol
Menthol
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tert -Butanol (2M2P)
tert -Pentanol (2M2B)
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Barbiturates Benzodiazepines Carbamates Flavonoids
Ampelopsin (dihydromyricetin)
Apigenin
Baicalein
Baicalin
Catechin
EGC
EGCG
Hispidulin
Luteolin
Skullcap constituents (e.g., baicalin )
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Desmethoxyyangonin
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Monoureides Neuroactive steroids Nonbenzodiazepines Phenols
Fospropofol
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Piperidinediones Pyrazolopyridines Quinazolinones Volatiles /gases
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Acetylglycinamide chloral hydrate
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Benzene
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Butylene
Centalun
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3-Hydroxybutanal
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Org 25,435
Phenytoin
Propanidid
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Seproxetine
Stiripentol
(e.g., sulfonmethane (sulfonal) , tetronal , trional )
Terpenoids (e.g., borneol )
Topiramate
Valerian constituents (e.g., isovaleric acid , isovaleramide , valerenic acid , )
Unsorted benzodiazepine site positive modulators: α-Pinene
See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators