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Divaplon ATC code
(6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-yl)-phenylmethanone
CAS Number PubChem CID ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) Formula C 17 H 17 N 3 O 2 Molar mass 295.336 g·mol−1 3D model (JSmol )
CCC1=C(N2C=C(N=C2N=C1OC)C(=O)C3=CC=CC=C3)C
InChI=1S/C17H17N3O2/c1-4-13-11(2)20-10-14(18-17(20)19-16(13)22-3)15(21)12-8-6-5-7-9-12/h5-10H,4H2,1-3H3
Key:NRJVHCSYLGLURI-UHFFFAOYSA-N
Divaplon (RU-32698 ) is a nonbenzodiazepine , anxiolytic and anticonvulsant drug from the pyrazolopyrimidine family of drugs. It acts as a partial agonist at the "benzodiazepine site" of the GABAA receptor in the brain.[1] [2] [3]
References [ ]
^ Feely M, Boyland P, Picardo A, Cox A, Gent JP (May 1989). "Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812". European Journal of Pharmacology . 164 (2): 377–80. doi :10.1016/0014-2999(89)90482-2 . PMID 2759183 . ^ Sanger DJ, Joly D, Perrault G (September 1995). "Benzodiazepine (omega) receptor partial agonists and the acquisition of conditioned fear in mice". Psychopharmacology . 121 (1): 104–8. doi :10.1007/BF02245596 . PMID 8539334 . S2CID 32627339 . ^ Pellón R, Ruíz A, Lamas E, Rodríguez C (February 2007). "Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats". Behavioural Pharmacology . 18 (1): 81–7. doi :10.1097/FBP.0b013e3280143212 . PMID 17218801 . S2CID 40188048 .
Anxiolytics (N05B )
5-HT1A R agonists GABAA R PAMs
Benzodiazepines :Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam # Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam # Medazepam Nordazepam Oxazepam Pinazepam Prazepam ; Others: Alpidem ‡ Barbiturates (e.g., phenobarbital )Carisoprodol Carbamates (e.g., meprobamate )Chlormezanone ‡ Ethanol (alcohol) Etifoxine Imepitoin ; Herbs: Kava Skullcap Valerian Gabapentinoids (α2 δ VDCC blockers )
Gabapentin Gabapentin enacarbil Phenibut Pregabalin Antidepressants
SSRIs escitalopram )SNRIs duloxetine )SARIs trazodone )TCAs clomipramine # )TeCAs mirtazapine )MAOIs phenelzine ); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine Sympatholytics (Antiadrenergics )
Alpha-1 blockers (e.g., prazosin )Alpha-2 agonists (e.g., clonidine , dexmedetomidine , guanfacine )Beta blockers (e.g., propranolol ) Others
Benzoctamine Cannabidiol Cycloserine Fabomotizole Hydroxyzine Kanna Lavender Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane ‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
# WHO-EM ‡ Withdrawn from marketClinical trials :
† Phase III § Never to phase III
GABA A receptor positive modulatorsAlcohols
Butanol Chloralodol Chlorobutanol (cloretone) Ethanol (alcohol) (alcoholic drink )Ethchlorvynol Isobutanol Isopropanol Menthol Methanol Methylpentynol Pentanol Petrichloral Propanol tert -Butanol (2M2P)tert -Pentanol (2M2B)Tribromoethanol Trichloroethanol Triclofos Trifluoroethanol Barbiturates Benzodiazepines Carbamates Flavonoids
Ampelopsin (dihydromyricetin) Apigenin Baicalein Baicalin Catechin EGC EGCG Hispidulin Luteolin Skullcap constituents (e.g., baicalin )Wogonin Imidazoles Kava constituents
Desmethoxyyangonin Kavain Methysticin Yangonin Monoureides Neuroactive steroids Nonbenzodiazepines Phenols
Fospropofol Propofol Thymol Piperidinediones Pyrazolopyridines Quinazolinones Volatiles /gases
Acetone Acetophenone Acetylglycinamide chloral hydrate Aliflurane Benzene Butane Butylene Centalun Chloral Chloral betaine Chloral hydrate Chloroform Cryofluorane Desflurane Dichloralphenazone Dichloromethane Diethyl ether Enflurane Ethyl chloride Ethylene Fluroxene Gasoline Halopropane Halothane Isoflurane Kerosine Methoxyflurane Methoxypropane Nitric oxide Nitrogen Nitrous oxide Norflurane Paraldehyde Propane Propylene Roflurane Sevoflurane Synthane Teflurane Toluene Trichloroethane (methyl chloroform) Trichloroethylene Vinyl ether Others/unsorted
3-Hydroxybutanal Avermectins (e.g., ivermectin )Bromide compounds (e.g., lithium bromide , potassium bromide , sodium bromide )Carbamazepine Chloralose Chlormezanone Clomethiazole DEABL Dihydroergolines (e.g., dihydroergocryptine , , dihydroergotamine , ergoloid (dihydroergotoxine) )Efavirenz Etazepine Etifoxine Fenamates (e.g., flufenamic acid , mefenamic acid , niflumic acid , tolfenamic acid )Fluoxetine Flupirtine Hopantenic acid Lanthanum Lavender oil Lignans (e.g., 4-O-methylhonokiol , honokiol , magnolol , obovatol )Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Niacinamide Org 25,435 Phenytoin Propanidid Retigabine (ezogabine) Safranal Seproxetine Stiripentol (e.g., sulfonmethane (sulfonal) , tetronal , trional )
Terpenoids (e.g., borneol )Topiramate Valerian constituents (e.g., isovaleric acid , isovaleramide , valerenic acid , )Unsorted benzodiazepine site positive modulators: α-Pinene See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators
Categories :
Drugs not assigned an ATC code Anxiolytics Aromatic ketones Ethers Imidazopyrimidines GABAA receptor positive allosteric modulators Hidden categories:
Chem-molar-mass both hardcoded and calculated Chemical pages without DrugBank identifier Articles without KEGG source Drugs with no legal status
