Triazolobenzodiazepine
Chemical structure of alprazolam, a common triazolobenzodiazepine
Triazolobenzodiazepines (TBZD) are a class of benzodiazepine (BZD) derivative pharmaceutical drugs. Chemically, they differ from other benzodiazepines by having an additional fused triazole ring.
Examples include:
- Adinazolam
- Alprazolam
- Bromazolam
- Clonazolam
- Estazolam
- Flualprazolam
- Flubromazolam
- Flunitrazolam
- Nitrazolam
- Pyrazolam
- Triazolam
- Zapizolam
Synthesis[]
Synthesis of 1-methyltriazolobenzodiazepines (alprazolam type) is possible by heating 1,4-benzodiazepin-2-thiones with hydrazine and acetic acid in n-butanol under reflux.[1]
References[]
- ^ Hester JB, Duchamp DJ, Chidester CG (1971): "A synthetic approach to new 1,4-benzodiazepine derivatives." Tetrahedron Letters, Vol. 12, pp. 1609-1612.
External links[]
Media related to Triazolobenzodiazepines at Wikimedia Commons
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- Triazolobenzodiazepines
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