Chlormerodrin
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IUPAC name
3-carbamoylamino-2-methoxypropylmercury(II) chloride
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Systematic IUPAC name
3-chloro-mercura-2-methoxy propylurea | |
Other names
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Identifiers | |
3D model (JSmol)
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ECHA InfoCard | 100.000.483 |
PubChem CID
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Properties | |
C5H11ClHgN2O2 | |
Molar mass | 367.20 g·mol−1 |
Appearance | Solid |
Melting point | 152.5 °C (306.5 °F; 425.6 K) |
11 g/l | |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Renal mercury poisoning |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Clinical data | |
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AHFS/Drugs.com | Medical Encyclopedia |
ATC code |
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Legal status | |
Legal status |
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Identifiers | |
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CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
ChEBI | |
ChEMBL | |
ECHA InfoCard | 100.000.483 |
Chemical and physical data | |
Formula | C5H11ClHgN2O2 |
Molar mass | 367.196 g·mol−1 |
3D model (JSmol) | |
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Chlormerodrin is a mercurial diuretic commercially traded from 1952[1] until 1974[2] that was once used to treat patients with heart failure,[3] but is no longer in widespread use.[4] The radiolabelled form (197Hg & 203Hg) had also been used for medical imaging of the kidney and brain[5][6] and the 197Hg form was even considered a contender for 99mTc by some physicians,[7] but was ultimately discontinued by the FDA in 1989.[8]
References[]
- ^ M. Sittig, Pharmaceutical Manufacturing Encyclopedia, Noyes Publications, Westwood, 1988.
- ^ J. R. Crout, Fed. Regist. 1974, 39, 42018–42019.
- ^ Leff WA, Nussbaum HE (April 1959). "Chlormerodrin: clinical effectiveness and absence of toxicity in congestive heart failure; report of a four-year study". British Medical Journal. 1 (5126): 883–9. doi:10.1136/bmj.1.5126.883. PMC 1992943. PMID 13629153.
- ^ PubChem. "Chlormerodrin". pubchem.ncbi.nlm.nih.gov. Retrieved 2021-09-23.
- ^ D. B. Sodee, B. Di Stefano, Ohio State Med. J. 1965, 61, 819–822.
- ^ Yamamoto, Y. L.; Feindel, W.; Zanelli, J. (1964-09-01). "Comparative study of radioactive chlormerodrin (Neohydrin) tagged with mercury 197 and mercury 203 for brain scanning". Neurology. 14 (9): 815–815. doi:10.1212/wnl.14.9.815. ISSN 0028-3878.
- ^ D. B. Sodee, J. Nucl. Med. 1968, 9, 645.
- ^ FDA, Approved Drug Products with Therapeutic Equivalence Evaluations, US Department Of Health And Human Service, 1989.
Categories:
- Drugs not assigned an ATC code
- Mercurial diuretics
- Ureas
- Withdrawn drugs
- Cardiovascular system drug stubs