Cyclin-dependent kinase inhibitor protein

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1jsuC:30-80 1h27E:30-35

Cyclin-dependent kinase inhibitor
Cyclin-dependent kinase inhibitor
	Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Identifiers
Symbol	CDI
Pfam	PF02234
InterPro	IPR003175
SCOP2	1jsu / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1jsuC:30-80 1h27E:30-35

A cyclin-dependent kinase inhibitor protein is a protein which inhibits the enzyme cyclin-dependent kinase (CDK). Several function as tumor suppressor proteins. Cell cycle progression is delayed or stopped by cyclin-dependent kinase inhibitors, abbreviated CDIs, CKIs or CDKIs. CDIs are involved in cell cycle arrest at the G₁ phase.

Seven cyclin-dependent kinase inhibitor proteins have thus far been identified. They are named by the small letter "p" followed by their molecular weight in kilodaltons. They are p15, p16, p18, p19, p21, p27, and p57.

Associated gene and target[]

Protein	Gene	Target
p16	CDKN2A	Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p15	CDKN2B	Cyclin-dependent kinase 4
p18	CDKN2C	Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p19	CDKN2D	Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p21 / WAF1	CDKN1A^[2]	Cyclin E1/Cyclin-dependent kinase 2
p27	CDKN1B	Cyclin D3/Cyclin-dependent kinase 4, Cyclin E1/Cyclin-dependent kinase 2
p57	CDKN1C	Cyclin E1/Cyclin-dependent kinase 2
	CDKN3	Cyclin-dependent kinase 2

References[]

^ Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325–31. doi:10.1038/382325a0. PMID 8684460. S2CID 4284942.
^ Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene. 18 (3): 813–22. doi:10.1038/sj.onc.1202367. PMID 9989833.

External links[]

Cyclin-Dependent+Kinase+Inhibitor+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

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[pmid8684460-1] Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325–31. doi:10.1038/382325a0. PMID 8684460. S2CID 4284942.

[pmid9989833-2] Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene. 18 (3): 813–22. doi:10.1038/sj.onc.1202367. PMID 9989833.

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