Intracellular calcium-sensing proteins

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Intracellular calcium-sensing proteins are proteins that act in the second messenger system.

Examples include:

calmodulin
calnexin
calreticulin
gelsolin^[1]

References[]

^ Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256.CS1 maint: uses authors parameter (link)

External links[]

Intracellular+Calcium-Sensing+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

Intracellular signaling peptides and proteins

MAP

see MAP kinase pathway

Calcium

G protein

cAMP:	Heterotrimeric G protein Gs/Gi Adenylate cyclase cAMP 3',5'-cyclic-AMP phosphodiesterase Protein kinase A
cGMP:	Transducin Gustducin Guanylate cyclase cGMP 3',5'-cyclic-GMP phosphodiesterase Protein kinase G
G alpha subunit G_α GNAO1 GNAI1 GNAI2 GNAI3 GNAT1 GNAT2 GNAT3 GNAZ GNAS GNAL GNAQ GNA11 GNA12 GNA13 GNA14
G beta-gamma complex G_β GNB1 GNB2 GNB3 GNB4 GNB5 G_γ GNGT1 GNGT2 GNG2 GNG3 GNG4 GNG5 GNG7 GNG11 GNG12 GNG13 BSCL2
G protein-coupled receptor kinase AMP-activated protein kinase

ARFs
Rabs
Ras
- HRAS
- KRAS
- NRAS
Rhos
Arfs
Ran
Rhebs
Raps
RGKs

Cyclin

Lipid

Phosphoinositide phospholipase C
Phospholipase C

Other protein kinase

Serine/threonine:	Casein kinase 1 2 eIF-2 kinase EIF2AK3 Glycogen synthase kinase GSK-3 GSK3A GSK3B IκB kinase CHUK IKK2 IKBKG Interleukin-1 receptor associated kinase IRAK1 IRAK2 IRAK3 IRAK4 Lim kinase LIMK1 LIMK2 p21-activated kinases PAK1 PAK2 PAK3 PAK4 Rho-associated protein kinase ROCK1 ROCK2 Ribosomal s6 kinase RPS6KA1
Tyrosine:	ZAP70 PTK2 PTK2B BTK
both	Dual-specificity kinase

Other protein phosphatase

Serine/threonine:	Protein phosphatase 2
Tyrosine:	protein tyrosine phosphatase:
both:	Dual-specificity phosphatase

Apoptosis

see apoptosis signaling pathway

GTP-binding protein regulators

see GTP-binding protein regulators

Other

Activating transcription factor 6
Signal transducing adaptor protein
I-kappa B protein
Mucin-4
Olfactory marker protein
Phosphatidylethanolamine binding protein
EDARADD
PRKCSH

see also deficiencies of intracellular signaling peptides and proteins

Cell signaling: calcium signaling and calcium metabolism

Cell membrane

Adhesion molecules	Cadherins CDH1 CDH2 CDH3 CDH4 CDH5 CDH4 CDH5 CDH6 CDH8 CDH9 CDH10 CDH11 CDH12 CDH13 CDH15 CDH16 CDH17
Calcium channels	Ligand-gated 5-HT3 receptor Ionotropic glutamate receptors AMPA receptors Kainate receptors NMDA receptors P2X receptors Voltage-gated L N P R T TRP channels TRPA TRPC TRPV
Calcium pumps	Sodium-calcium exchangers SLC3A2 SLC8A1
GPCRs	Calcium-sensing receptor
Annexins	A1 A2 A3 A4 A5 A6 A7 A8-L2 A9 A11 A13

Intracellular signaling

Second messengers	IP3 NAADP cADPR
Intracellular channels	IP3 receptor Ryanodine receptor Calcium-induced calcium release
Intracellular pumps	SERCA ATP2A1 ATP2A2 ATP2A3 Sodium-calcium exchangers SLC8B1 SLC24A5
Sensors and chelators	Calbindin Calmodulin CALM1 CALM2 CALM3 CALML3 CALML5 Calsequestrin Calretinin Gelsolin Neuronal calcium sensors Calsenilin Frequenin GUCA 1A 1B Hippocalcin Neurocalcin Recoverin Visinin Pervalbumin Phospholamban Sarcalumenin Synaptotagmins SYT1 SYT2 SYT3 SYT4 SYT5 SYT6 SYT7 SYT9 SYT11 SYT13 SYT14 S100 S100P Troponin C TNNC1 TNNC2
Calcium-dependent chaperones	Calreticulin Calnexin HSPA5 HSP90B1
Calcium-dependent kinases	CaM kinases CAMK1 CAMK2 A B D G CAMK3 CAMK4 Protein kinase C
Calcium-dependent proteases	Calpains CAPN1 CAPN2 CAPN3 CAPN4 CAPN5 CAPN6 CAPN8 CAPN9 CAPN10
Indirect regulators	Calcitonin Parathyroid hormone Vitamin D Vitamin K

Extracellular chelators

Extracellular matrix proteins	Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix gla protein Osteonectin SIBLINGs Bone sialoprotein Dentin matrix phosphoprotein Dentin sialophosphoprotein Osteopontin
Secreted hormones	Osteocalcin

Calcium-binding domains

Cell signaling: calcium signaling and calcium metabolism

Cell membrane

Adhesion molecules	Cadherins CDH1 CDH2 CDH3 CDH4 CDH5 CDH4 CDH5 CDH6 CDH8 CDH9 CDH10 CDH11 CDH12 CDH13 CDH15 CDH16 CDH17
Calcium channels	Ligand-gated 5-HT3 receptor Ionotropic glutamate receptors AMPA receptors Kainate receptors NMDA receptors P2X receptors Voltage-gated L N P R T TRP channels TRPA TRPC TRPV
Calcium pumps	Sodium-calcium exchangers SLC3A2 SLC8A1
GPCRs	Calcium-sensing receptor
Annexins	A1 A2 A3 A4 A5 A6 A7 A8-L2 A9 A11 A13

Intracellular signaling

Second messengers	IP3 NAADP cADPR
Intracellular channels	IP3 receptor Ryanodine receptor Calcium-induced calcium release
Intracellular pumps	SERCA ATP2A1 ATP2A2 ATP2A3 Sodium-calcium exchangers SLC8B1 SLC24A5
Sensors and chelators	Calbindin Calmodulin CALM1 CALM2 CALM3 CALML3 CALML5 Calsequestrin Calretinin Gelsolin Neuronal calcium sensors Calsenilin Frequenin GUCA 1A 1B Hippocalcin Neurocalcin Recoverin Visinin Pervalbumin Phospholamban Sarcalumenin Synaptotagmins SYT1 SYT2 SYT3 SYT4 SYT5 SYT6 SYT7 SYT9 SYT11 SYT13 SYT14 S100 S100P Troponin C TNNC1 TNNC2
Calcium-dependent chaperones	Calreticulin Calnexin HSPA5 HSP90B1
Calcium-dependent kinases	CaM kinases CAMK1 CAMK2 A B D G CAMK3 CAMK4 Protein kinase C
Calcium-dependent proteases	Calpains CAPN1 CAPN2 CAPN3 CAPN4 CAPN5 CAPN6 CAPN8 CAPN9 CAPN10
Indirect regulators	Calcitonin Parathyroid hormone Vitamin D Vitamin K

Extracellular chelators

Extracellular matrix proteins	Fibulins FBLN1 FBLN2 FBLN3 FBLN4 FBLN5 Hemicentin 1 Matrix gla protein Osteonectin SIBLINGs Bone sialoprotein Dentin matrix phosphoprotein Dentin sialophosphoprotein Osteopontin
Secreted hormones	Osteocalcin

Calcium-binding domains

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