Cysteine lyase
| cysteine lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.4.1.10 | ||||||||
| CAS no. | 9079-86-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a cysteine lyase (EC 4.4.1.10) [1] is an enzyme that catalyzes the chemical reaction
- L-cysteine + sulfite L-cysteate + hydrogen sulfide
Thus, the two substrates of this enzyme are L-cysteine and sulfite, whereas its two products are L-cysteate and hydrogen sulfide.
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine hydrogen-sulfide-lyase (adding sulfite L-cysteate-forming). Other names in common use include cysteine (sulfite) lyase, and L-cysteine hydrogen-sulfide-lyase (adding sulfite). This enzyme participates in cysteine metabolism and taurine metabolism. It employs one cofactor, pyridoxal phosphate.
Evolution[]
Genes encoding cysteine lyase (CL) originated around 300 million years ago by a tandem gene duplication and neofunctionalization of cystathionine beta-lyase (CBS) shortly after the split of mammalian and reptilian lineages. CL genes are found only in Sauropsida where are involved in a metabolic pathway for sulfur metabolism in the chicken egg. [2]
References[]
- ^ Tolosa EA, Chepurnova NK, Khomutov RM, Severin ES (1969). "Reactions catalysed by cysteine lyase from the yolk sac of chicken embryo". Biochim. Biophys. Acta. 171 (2): 369–71. doi:10.1016/0005-2744(69)90174-0. PMID 5813025.
- ^ Malatesta M, Mori G, Acquotti D, Campanini B, Peracchi A, Antin PB, Percudani R (2020). "Birth of a pathway for sulfur metabolism in early amniote evolution". Nat Ecol Evol. 4 (9): 1239–1246. doi:10.1038/s41559-020-1232-4. PMC 8364350. PMID 32601391.
- EC 4.4.1
- Pyridoxal phosphate enzymes
- Enzymes of unknown structure
- Lyase stubs