D-threo-aldose 1-dehydrogenase

In enzymology, a D-threo-aldose 1-dehydrogenase (EC 1.1.1.122) is an enzyme that catalyzes the chemical reaction

a D-threo-aldose + NAD⁺ ${\displaystyle \rightleftharpoons }$ a D-threo-aldono-1,5-lactone + NADH + H⁺

Thus, the two substrates of this enzyme are and NAD⁺, whereas its 3 products are , NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-threo-aldose:NAD⁺ 1-oxidoreductase. Other names in common use include L-fucose dehydrogenase, (2S,3R)-aldose dehydrogenase, dehydrogenase, L-fucose, and L-fucose (D-arabinose) dehydrogenase. This enzyme participates in .

References[]

• Sasajima KI, Sinskey AJ (1979). "Oxidation of L-glucose by a Pseudomonad". Biochim. Biophys. Acta. 571 (1): 120–6. doi:10.1016/0005-2744(79)90232-8. PMID 40609.
• Schachter H, Sarney J, McGuire EJ, Roseman S (1969). "Isolation of diphosphopyridine nucleotide-dependent L-fucose dehydrogenase from pork liver". J. Biol. Chem. 244 (17): 4785–92. PMID 4309152.