Diethylcarbamazine
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Other names | N, N-diethyl-4-methyl-1-piperazine carboxamide |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Routes of administration | by mouth |
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ECHA InfoCard | 100.001.840 |
Chemical and physical data | |
Formula | C10H21N3O |
Molar mass | 199.298 g·mol−1 |
3D model (JSmol) | |
Melting point | 47 to 49 °C (117 to 120 °F) |
Diethylcarbamazine (DEC) is a medication used in the treatment of filariasis including lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis.[1] It may also be used for prevention of loiasis in those at high risk.[1] While it has been used for onchocerciasis (river blindness), ivermectin is preferred.[2] It is taken by mouth.[3]
Common side effects include itching, facial swelling, headaches, and feeling tired.[3] Other side effects include vision loss and dizziness.[3] It is a recommended treatment in pregnancy and appears to be safe for the baby.[4][5] The World Health Organization; however, recommends waiting until after pregnancy for treatment when feasible.[2] It is made from 4-methyl-piperazine.[6]
Diethylcarbamazine was discovered in 1947.[7] It is on the World Health Organization's List of Essential Medicines.[8] It is not commercially available in the United States but can be acquired from the Centers for Disease Control and Prevention.[1]
Medical uses[]
DEC is indicated for treatment of individual patients with certain filarial diseases, including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia; and loiasis.[citation needed]
In cases of onchocerciasis, another common filarial parasite, the drug is effective[citation needed].
DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used to prevent heartworm in dogs.[citation needed]
Now, the WHO recommends prescribing DEC to patients who are infected with microfilariae of filarial parasites and also to control transmission of infection in filariasis-endemic areas.[citation needed]
Contraindications are previous history of heart problems, gastrointestinal problems, and allergies.[medical citation needed]
In India and China, diethylcarbamazine has been added to salt to combat lymphatic filariasis.[9]
Mechanism[]
DEC is an inhibitor of arachidonic acid metabolism in microfilariae. This makes the microfilariae more susceptible to innate immune attack, but does not kill the parasites outright.[10]
Trade names[]
- Hetrazan
- Carbilazine
- Caricide
- Cypip
- Ethodryl
- Notézine
- Spatonin
- Filaribits
- Banocide Forte
- Eofil
References[]
- ^ Jump up to: a b c "Our Formulary Infectious Diseases Laboratories CDC". www.cdc.gov. 22 September 2016. Archived from the original on 16 December 2016. Retrieved 7 December 2016.
- ^ Jump up to: a b World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 91. hdl:10665/44053. ISBN 9789241547659.
- ^ Jump up to: a b c "Diethylcarbamazine Advanced Patient Information - Drugs.com". www.drugs.com. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
- ^ Sweet, Richard L.; Gibbs, Ronald S. (2009). Infectious Diseases of the Female Genital Tract. Lippincott Williams & Wilkins. p. 382. ISBN 9780781778152. Archived from the original on 2017-09-10.
- ^ Herbert-Ashton, Marilyn; Clarkson, Nancy Elaine (2005). Quick Look Nursing: Pharmacology. Jones & Bartlett Learning. p. 48. ISBN 9780763735951. Archived from the original on 2017-09-10.
- ^ "WHO Model Prescribing Information: Drugs Used in Parasitic Diseases - Second Edition: Helminths: Lymphatic filariasis: Diethylcarbamazine". apps.who.int. 1995. p. 152. Archived from the original on 20 November 2016. Retrieved 8 December 2016.
- ^ Busvine, James (2012). Disease Transmission by Insects: Its Discovery and 90 Years of Effort to Prevent it. Springer Science & Business Media. p. 260. ISBN 9783642457166. Archived from the original on 2017-09-10.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ [1] WHO: Unfulfilled potential: using diethylcarbamazine-fortified salt to eliminate lymphatic filariasis
- ^ El-Shahawi, G. A.; Abdel-Latif, M; Saad, A. H.; Bahgat, M (2010). "Setaria equina: In vivo effect of diethylcarbamazine citrate on microfilariae in albino rats". Experimental Parasitology. 126 (4): 603–10. doi:10.1016/j.exppara.2010.06.022. PMID 20599991.
External links[]
- "Diethylcarbamazine". Drug Information Portal. U.S. National Library of Medicine.
- Antiparasitic agents
- Piperazines
- Ureas
- World Health Organization essential medicines
- Lymphatic filariasis