From Wikipedia, the free encyclopedia
Lidoflazine AHFS /Drugs.com International Drug Names ATC code
2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
CAS Number PubChem CID ChemSpider UNII KEGG CompTox Dashboard (EPA ) ECHA InfoCard 100.020.285 Formula C 30 H 35 F 2 N 3 O Molar mass 491.627 g·mol−1 3D model (JSmol ) Melting point 159 to 161 °C (318 to 322 °F) Solubility in water Almost insoluble in water(<0.01%); Very soluble in chloroform(>50%); mg/mL (20 °C)
CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChI=1S/C30H35F2N3O/c1-22-5-3-6-23(2)30(22)33-29(36)21-35-19-17-34(18-20-35)16-4-7-28(24-8-12-26(31)13-9-24)25-10-14-27(32)15-11-25/h3,5-6,8-15,28H,4,7,16-21H2,1-2H3,(H,33,36)
N Key:ZBIAKUMOEKILTF-UHFFFAOYSA-N
N
N Y (what is this?)
Lidoflazine is a piperazine calcium channel blocker . It is a coronary vasodilator with some antiarrhythmic action.[1] Lidoflazine was discovered at Janssen Pharmaceutica in 1964.
Physical properties [ ]
Solubility at room temperature [ ]
Extracted from[1]
Solvent
0.01
N
0.1
N
%
pH
%
pH
Hydrochloric Acid
0.4
3.0
0.7
1.9
Tartaric Acid
0.3
3.1
1.0
2.5
Citric Acid
0.3
3.1
0.5
2.5
Lactic Acid
0.2
3.4
0.7
2.9
Acetic Acid
0.1
3.5
0.4
3.8
References [ ]
Further reading [ ]
Schaper WK, Xhonneux R, Jageneau AH (November 1965). "Stimulation of the coronary collateral circulation by lidoflazine (R 7904)". Naunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie . 252 (1): 1–8. doi :10.1007/bf00246424 (inactive 31 October 2021). PMID 4222721 . {{cite journal }}
: CS1 maint: DOI inactive as of October 2021 (link )
Calcium
Potassium
VGKCs
Blockers
hERG (KCNH2, Kv 11.1)-specific: Ajmaline
Amiodarone
AmmTX3
Astemizole
Azaspiracid
AZD1305
Azimilide
Bedaquiline
BeKm-1
BmTx3
BRL-32872
Chlorpromazine
Cisapride
Clarithromycin
Darifenacin
Dextropropoxyphene
Diallyl trisulfide
Domperidone
E-4031
Ergtoxins
Erythromycin
Gigactonine
Haloperidol
Ketoconazole
Norpropoxyphene
Orphenadrine
Pimozide
PNU-282,987
Promethazine
Quinidine
Ranolazine
Roxithromycin
Sertindole
Solifenacin
Tamulotoxin
Terodiline
Terfenadine
Thioridazine
Tolterodine
Vanoxerine
Vernakalant
Activators
KCNQ (Kv 7) -specific: Flupirtine
Retigabine
IRKs
KCa
Blockers
BKCa -specific: Ethanol (alcohol)
GAL-021
Activators
K2Ps
Blockers
12-O-Tetradecanoylphorbol-13-acetate
Arachidonic acid
Fluoxetine
Norfluoxetine
Activators
Sodium
VGSCs
Blockers
Toxins: Conotoxins
Neosaxitoxin
Saxitoxin
Tetrodotoxin
Zetekitoxin AB
Others: Buprenorphine
Evenamide
Menthol (mint )
Safinamide
Tricyclic antidepressants
Activators
ENaC
Blockers
Amiloride
Benzamil
Triamterene
Activators
ASICs
Blockers
Amiloride
Aspirin
Ibuprofen
Chloride
Others
See also: Receptor/signaling modulators • Transient receptor potential channel modulators
Piperazines
Simple piperazines(no additional rings)
Aminoethylpiperazine
Diethylcarbamazine
HEPPS
Midafotel
Piperazine
PIPES
Phenylpiperazines
2C-B-PP
3,4-CFP
Acaprazine
Antrafenine
Aripiprazole
Batoprazine
Bifeprunox
BRL-15,572
Ciprofloxacin
CSP-2503
Dapiprazole
DCPP
DMPP
Diphenylpiperazine
Dropropizine
EGIS-12,233
Elopiprazole
Eltoprazine
Enpiprazole
Ensaculin
Etoperidone
Flesinoxan
Fluanisone
Flibanserin
Fluprazine
Itraconazole
Ketoconazole
Levodropropizine
Lorpiprazole
mCPP
Mefway
MeOPP
Mepiprazole
Naftopidil
Naluzotan
Naphthylpiperazine
Nefazodone
Niaprazine
Oxypertine
Pardoprunox
pCPP
pFPP
Posaconazole
S-14,506
S-14,671
S-15,535
SB-258,585
SB-271,046
SB-357,134
SB-399,885
Sonepiprazole
TFMPP
Tolpiprazole
Trazodone
Urapidil
Vesnarinone
Vilazodone
Vortioxetine
WAY-100,135
WAY-100,635
Benzylpiperazines Diphenylalkylpiperazines (benzhydrylalkylpiperazines) Pyrimidinylpiperazines Pyridinylpiperazines Benzo(iso)thiazolyl piperazines Tricyclics (piperazine attached via side chain) Others/Uncategorized
[1]
Categories :
Piperazines HERG blocker Calcium channel blockers Acetanilides Fluoroarenes Janssen Pharmaceutica Belgian inventions Cardiovascular system drug stubs Hidden categories:
Articles with changed ChemSpider identifier ECHA InfoCard ID from Wikidata Articles with changed InChI identifier Articles without EBI source Chemical pages without DrugBank identifier Drugs with no legal status Drugboxes which contain changes to verified fields Drugboxes which contain changes to watched fields CS1 maint: DOI inactive as of October 2021 All stub articles