Estradiol 17alpha-dehydrogenase

In enzymology, an estradiol 17alpha-dehydrogenase (EC 1.1.1.148) is an enzyme that catalyzes the chemical reaction

estradiol-17alpha + NAD(P)⁺ ${\displaystyle \rightleftharpoons }$ estrone + NAD(P)H + H⁺

The three substrates of this enzyme are estradiol-17alpha, NAD⁺, and NADP⁺, whereas its four products are estrone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 17alpha-hydroxysteroid:NAD(P)⁺ 17-oxidoreductase. Other names in common use include 17alpha-estradiol dehydrogenase, 17alpha-hydroxy steroid dehydrogenase, 17alpha-hydroxy steroid oxidoreductase, 17alpha-hydroxysteroid oxidoreductase, and estradiol 17alpha-oxidoreductase. This enzyme participates in androgen and estrogen metabolism.

References[]

• Renwick AG, Engel LL (1967). "The partial purification of 17 alpha- and 17 beta-estradiol dehydrogenase activities from chicken liver". Biochim. Biophys. Acta. 146 (2): 336–48. doi:10.1016/0005-2744(67)90220-3. PMID 4383682.