FGR (gene)

FGR
Identifiers
Aliases	FGR, SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, FGR proto-oncogene, Src family tyrosine kinase
External IDs	OMIM: 164940 MGI: 95527 HomoloGene: 3842 GeneCards: FGR
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 27,612,064 bp[1] End 27,635,185 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.3|4 66.11 cM Start 132,701,406 bp[2] End 132,729,221 bp[2]
RNA expression pattern Bgee Top expressed in blood right lung spleen bone marrow upper lobe of left lung cancellous bone appendix lung synovial membrane visceral pleura More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity immunoglobulin receptor binding kinase activity GO:0001948 protein binding Fc-gamma receptor I complex binding ATP binding protein kinase binding protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity phosphotyrosine residue binding signaling receptor binding Cellular component cytoplasm cytosol cell projection membrane extrinsic component of cytoplasmic side of plasma membrane mitochondrial intermembrane space ruffle membrane mitochondrion actin cytoskeleton mitochondrial inner membrane extracellular exosome cytoskeleton extracellular region plasma membrane aggresome secretory granule lumen Biological process cell differentiation regulation of innate immune response Fc-gamma receptor signaling pathway involved in phagocytosis phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway immune system process positive regulation of cell migration response to virus positive regulation of mast cell degranulation immune response-regulating cell surface receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase activity protein phosphorylation regulation of cell population proliferation regulation of cell shape peptidyl-tyrosine autophosphorylation integrin-mediated signaling pathway protein autophosphorylation positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation regulation of protein kinase activity regulation of phagocytosis GO:0051637 defense response to Gram-positive bacterium cell migration innate immune response neutrophil degranulation bone mineralization skeletal system morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2268	14191
Ensembl	ENSG00000000938	ENSMUSG00000028874
UniProt	P09769	P14234
RefSeq (mRNA)	NM_001042729 NM_001042747 NM_005248	NM_010208
RefSeq (protein)	NP_001036194 NP_001036212 NP_005239	NP_034338
Location (UCSC)	Chr 1: 27.61 – 27.64 Mb	Chr 4: 132.7 – 132.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.^[5][6]

Function[]

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.^[6]

Discovery[]

The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.^[7]

Interactions[]

FGR (gene) has been shown to interact with Wiskott-Aldrich syndrome protein.^[8][9][10]

References[]

Further reading[]

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