|
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Angiopoietin |
- Antagonists: Angiopoietin 2
- Kinase inhibitors:
- Rebastinib
- Antibodies: Evinacumab (against angiopoietin 3)
- Nesvacumab (against angiopoietin 2)
|
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CNTF | |
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EGF (ErbB) | EGF (ErbB1/HER1) |
- Kinase inhibitors: Afatinib
- Brigatinib
- Canertinib
- Dacomitinib
- Erlotinib
- Gefitinib
- Grandinin
- Icotinib
- Lapatinib
- Neratinib
- Osimertinib
- Vandetanib
|
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ErbB2/HER2 |
- Antibodies: Ertumaxomab
- Pertuzumab
- Trastuzumab
- Trastuzumab deruxtecan
- Trastuzumab emtansine
- Kinase inhibitors: Afatinib
- Lapatinib
- Mubritinib
- Neratinib
- Tucatinib
|
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ErbB3/HER3 | |
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ErbB4/HER4 | |
---|
|
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FGF | FGFR1 | |
---|
FGFR2 |
- Agonists:
- FGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF), 8, 9, 10 (KGF2), 17, 18, 22)
- Palifermin
- Selpercatinib
- Sprifermin
- Trafermin
- Kinase inhibitors: Infigratinib
|
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FGFR3 |
- Antibodies: Burosumab (against FGF23)
|
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FGFR4 | |
---|
Unsorted | |
---|
|
---|
HGF (c-Met) |
- Agonists:
- Hepatocyte growth factor
|
---|
IGF | IGF-1 |
- Agonists: des(1-3)IGF-1
- Insulin-like growth factor-1 (somatomedin C)
- IGF-1 LR3
- Insulin-like growth factor-2 (somatomedin A)
- Insulin
- Mecasermin
- Mecasermin rinfabate
- Kinase inhibitors:
- Linsitinib
|
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IGF-2 |
- Agonists: Insulin-like growth factor-2 (somatomedin A)
|
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Others |
- Cleavage products/derivatives with unknown target:
- Trofinetide
|
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|
---|
LNGF (p75NTR) |
- Antagonists:
- Dexamethasone
- Testosterone
|
---|
PDGF |
- Agonists: Becaplermin
- Platelet-derived growth factor (A, B, C, D)
|
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RET (GFL) | |
---|
SCF (c-Kit) | |
---|
TGFβ | |
---|
Trk | TrkA |
- Antagonists:
- Dexamethasone
- FX007
- Testosterone
- Negative allosteric modulators:
- Kinase inhibitors:
- Entrectinib
- K252a
- Larotrectinib
- Lestaurtinib
- Rebastinib
- )
|
---|
TrkB | |
---|
TrkC | |
---|
|
---|
VEGF |
- Decoy receptors: Aflibercept
|
---|
Others |
- Additional growth factors: Adrenomedullin
- Colony-stimulating factors (see here instead)
- Connective tissue growth factor (CTGF)
- Ephrins (A1, A2, A3, A4, A5, B1, B2, B3)
- Erythropoietin (see here instead)
- Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
- Glia maturation factor (GMF)
- Hepatoma-derived growth factor (HDGF)
- Interleukins/T-cell growth factors (see here instead)
- Leukemia inhibitory factor (LIF)
- Macrophage-stimulating protein (MSP; HLP, HGFLP)
- Midkine (NEGF2)
- Migration-stimulating factor (MSF; PRG4)
- Oncomodulin
- Pituitary adenylate cyclase-activating peptide (PACAP)
- Pleiotrophin
- Renalase
- Thrombopoietin (see here instead)
- Wnt signaling proteins
- Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)
|
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