Neurotrophin-4

NTF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HCF, 1B8M, 1B98
Identifiers
Aliases	NTF4, GLC10, GLC1O, NT-4, NT-4/5, NT-5, NT4, NT5, NTF5, neurotrophin 4
External IDs	OMIM: 162662 MGI: 97381 HomoloGene: 4503 GeneCards: NTF4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,065,054 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,066,603 bp
RNA expression pattern
	Top expressed in
	prostate; ; muscle of leg; ; zone of skin; ; vagina;
	More reference expression data
	n/a
Gene ontology
Molecular function	neurotrophin p75 receptor binding; signaling receptor binding; GO:0001948 protein binding; growth factor activity;
Cellular component	GO:0016023 cytoplasmic vesicle; extracellular region; extracellular space; synaptic vesicle; axon; dendrite;
Biological process	negative regulation of neuron apoptotic process; regulation of neuron differentiation; adult locomotory behavior; sensory organ boundary specification; cell-cell signaling; neuron projection morphogenesis; innervation; negative regulation of cell death; long-term memory; taste bud development; mechanoreceptor differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; ganglion mother cell fate determination; epidermis development; regulation of signaling receptor activity; activation of phospholipase C activity; neurotrophin TRK receptor signaling pathway; peripheral nervous system development; memory; nerve development; nerve growth factor signaling pathway; modulation of chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	4909
	78405
	ENSG00000225950
	ENSMUSG00000074121
	P34130
	Q80VU4
	NM_006179; NM_001395489
	NM_198190
	NP_006170
	NP_937833
	Wikidata
View/Edit Human	View/Edit Mouse

Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene.^[5] It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase.

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000225950 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074121 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: neurotrophin 4".

Further reading[]

Childs AJ, Bayne RA, Murray AA, et al. (2010). "Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development". Dev. Dyn. 239 (4): 1211–9. doi:10.1002/dvdy.22252. PMC 3410523. PMID 20175187.
Vithana EN, Nongpiur ME, Venkataraman D, et al. (2010). "Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population". Mol. Vis. 16: 1640–5. PMC 2927376. PMID 20806036.
Truzzi F, Marconi A, Lotti R, et al. (2008). "Neurotrophins and their receptors stimulate melanoma cell proliferation and migration". J. Invest. Dermatol. 128 (8): 2031–40. doi:10.1038/jid.2008.21. PMID 18305571.
Harel S, Jin S, Fisch B, et al. (2006). "Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults". Mol. Hum. Reprod. 12 (6): 357–65. doi:10.1093/molehr/gal033. PMID 16648150.
Ribasés M, Hervás A, Ramos-Quiroga JA, et al. (2008). "Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder". Biol. Psychiatry. 63 (10): 935–45. doi:10.1016/j.biopsych.2007.11.004. PMID 18179783. S2CID 15820930.
Chen ZY, Ieraci A, Teng H, et al. (2005). "Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway". J. Neurosci. 25 (26): 6156–66. doi:10.1523/JNEUROSCI.1017-05.2005. PMC 1201519. PMID 15987945.
Pasutto F, Matsumoto T, Mardin CY, et al. (2009). "Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma". Am. J. Hum. Genet. 85 (4): 447–56. doi:10.1016/j.ajhg.2009.08.016. PMC 2756554. PMID 19765683.
Ibáñez CF (1996). "Neurotrophin-4: the odd one out in the neurotrophin family". Neurochem. Res. 21 (7): 787–93. doi:10.1007/BF02532301. PMID 8873083. S2CID 10824679.
Nalbandian A, Pang AL, Rennert OM, et al. (2005). "A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression". Differentiation. 73 (8): 385–96. doi:10.1111/j.1432-0436.2005.00040.x. PMID 16316409.
Liu Y, Liu W, Crooks K, et al. (2010). "No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma". Am. J. Hum. Genet. 86 (3): 498–9, author reply 500. doi:10.1016/j.ajhg.2009.11.018. PMC 2833375. PMID 20215012.
Götz R, Schartl M (1994). "The conservation of neurotrophic factors during vertebrate evolution". Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 108 (1): 1–10. doi:10.1016/1367-8280(94)90082-5. PMID 8061955.
Gratacòs M, EscaramÃs G, Bustamante M, et al. (2010). "Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease". J Psychiatr Res. 44 (13): 834–40. doi:10.1016/j.jpsychires.2010.01.009. PMID 20219210.
Chakrabarti B, Dudbridge F, Kent L, et al. (2009). "Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome". Autism Research. 2 (3): 157–77. doi:10.1002/aur.80. PMID 19598235. S2CID 18239947.
Mizuno N, Shiba H, Inui T, et al. (2008). "Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells". J. Periodontol. 79 (11): 2182–9. doi:10.1902/jop.2008.070402. PMID 18980528.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rao KN, Kaur I, Parikh RS, et al. (2010). "Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an Indian population" (PDF). Invest. Ophthalmol. Vis. Sci. 51 (10): 4937–41. doi:10.1167/iovs.10-5553. PMID 20463313.
Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
Mercader JM; Saus E; Agüera Z; et al. (2008). "Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders". Hum. Mol. Genet. 17 (9): 1234–44. doi:10.1093/hmg/ddn013. PMID 18203754.
Walz JC; Magalhães PV; Giglio LM; et al. (2009). "Increased serum neurotrophin-4/5 levels in bipolar disorder". J Psychiatr Res. 43 (7): 721–3. doi:10.1016/j.jpsychires.2008.10.005. PMID 19081579.
Prakash YS, Iyanoye A, Ay B, et al. (2006). "Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (3): L447–56. doi:10.1152/ajplung.00501.2005. PMID 16648236.

External links[]

neurotrophin+4 at the US National Library of Medicine Medical Subject Headings (MeSH)
neurotrophin+5 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000225950 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074121 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: neurotrophin 4".

[1]

[2]

[3]

[4]

[5]

v t Cell signaling: Nervous tissue: Neurotrophic factors
Neurotrophins	NGF BDNF NT-3 NT-4
GDNF family	GDNF Artemin Neurturin Persephin
Ephrins	A1 A2 A3 A4 A5 B1 B2 B3
CNTF family	CNTF LIF IL-6
Other	GMF IGF-1 Neuregulins 1 2 3 4 PACAP VEGF

Neurotrophin-4

Contents

See also[]

References[]

Further reading[]

External links[]