Sprifermin Other names AS-902330; rhFGF18; L-Methionyl(human fibroblast growth factor 18 (FGF-18, zFGF5)-(1-169)-peptide)[1] : 45 CAS Number UNII Formula C 876 H 1396 N 258 O 256 S 6 Molar mass 830 .71−1 3D model (JSmol )
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Sprifermin (INN ) (developmental code name AS-902330 ), also known as recombinant human fibroblast growth factor 18 (rhFGF18 ), is a recombinant form of human fibroblast growth factor 18 (FGF18)[1] : 45 Merck and Nordic Bioscience for the treatment of osteoarthritis .[2] potent agonist of the FGFR2 and FGFR3 .[3] [4]
As of 2017, the drug is in phase II clinical trials for the treatment of osteoarthritis.[2] [5]
2019 outcomes of phase 2 clinical trial for KOA [knee osteoarthritis] shows improvement in cartilage thickness, but fails to satisfy tests like the WOMAC , therefore failing to satisfy its primary end points.[6]
However in some subgroups where cartilage thickness is of specific concern, clinical significance might be achieved.[7]
References [ ]
^ a b "International Nonproprietary Names for Pharmaceutical Substances (INN)" (PDF) . World Health Organization.^ a b "Sprifermin - Merck" . Adis Insight . Springer Nature Switzerland AG.^ Barrett KE, Ghishan FK, Merchant JL, Said HM, Wood JD (10 May 2006). Physiology of the Gastrointestinal Tract ISBN 978-0-08-045615-7 ^ Said HM (4 July 2012). Physiology of the Gastrointestinal Tract, Two Volume Set ISBN 978-0-12-382027-3 ^ Clinical trial number NCT01919164 ClinicalTrials.gov
^ Hochberg MC, Guermazi A, Guehring H, Aydemir A, Wax S, Fleuranceau-Morel P, et al. (October 2019). "Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial" . JAMA . 322 (14): 1360–1370. doi :10.1001/jama.2019.14735 . PMC 6784851 PMID 31593273 . ^ Gühring H, Kraines J, Moreau F, Daelken B, Ladel C, Wirth W, Conaghan PG, Eckstein F, Hochberg M (2019-06-01). "Op0010 Cartilage Thickness Modification with Sprifermin in Knee Osteoarthritis Patients Translates into Symptomatic Improvement Over Placebo in Patients at Risk of Further Structural and Symptomatic Progression: Post-Hoc Analysis of the Phase Ii Forward Trial" . Annals of the Rheumatic Diseases . 78 (Suppl 2): 70–71. doi :10.1136/annrheumdis-2019-eular.1216 ISSN 0003-4967 .
External links [ ]
Angiopoietin
Antagonists: Angiopoietin 2 Kinase inhibitors: Rebastinib Antibodies: Evinacumab (against angiopoietin 3)Nesvacumab (against angiopoietin 2) CNTF EGF (ErbB)
FGF
FGFR1 FGFR2
Agonists: FGF (1 , 2 (bFGF) , 3 , 4 , 5 , 6 , 7 (KGF ), 8 , 9 , 10 (KGF2) , 17 , 18 , 22 )Palifermin Selpercatinib Sprifermin Trafermin FGFR3 FGFR4 Unsorted
HGF (c-Met)
Agonists : Hepatocyte growth factor IGF
LNGF (p75NTR ) PDGF RET (GFL)
SCF (c-Kit) TGFβ Trk
TrkA
Negative allosteric modulators: TrkB TrkC
VEGF
Decoy receptors: Aflibercept Others
Additional growth factors: Adrenomedullin Colony-stimulating factors (see here instead)Connective tissue growth factor (CTGF) Ephrins (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )Erythropoietin (see here instead)Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF) Glia maturation factor (GMF) Hepatoma-derived growth factor (HDGF) Interleukins /T-cell growth factors (see here instead)Leukemia inhibitory factor (LIF) Macrophage-stimulating protein (MSP; HLP, HGFLP) Midkine (NEGF2) Migration-stimulating factor (MSF; PRG4) Oncomodulin Pituitary adenylate cyclase-activating peptide (PACAP) Pleiotrophin Renalase Thrombopoietin (see here instead)Wnt signaling proteins Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)
