Ganitumab
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Monoclonal antibody | |
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Type | Whole antibody |
Source | Human |
Target | IGF-1R |
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Formula | C6472H10028N1728O2020S42 |
Molar mass | 145712.01 g·mol−1 |
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Ganitumab is a human monoclonal antibody against type 1 insulin-like growth factor receptor (IGF1R), designed for the treatment of cancers.[1][2]
Ganitumab was developed by Amgen. A phase III clinical trial (for metastatic pancreatic cancer) was abandoned in August 2012.[3][4]
References[]
- ^ "Statement On A Nonproprietary Name Adopted By The USAN Council: Ganitumab" (PDF). .
- ^ Martínez P, Sales Fidalgo PA, Felip E (October 2014). "Ganitumab for the treatment of small-cell lung cancer". Expert Opinion on Investigational Drugs. 23 (10): 1423–32. doi:10.1517/13543784.2014.951434. PMID 25189625.
- ^ "Amgen Pulls Cancer Drug". 10 Aug 2012. Archived from the original on 2013-07-23.
- ^ "Amgen (AMGN) Terminates Ganitumab Pancreatic Cancer Trial". 8 Aug 2012. Archived from the original on 2012-08-10.
Monoclonal antibodies for tumors | |
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Tumor | |
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Growth factor receptor modulators | |||||||||||
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Angiopoietin |
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CNTF |
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EGF (ErbB) |
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FGF |
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HGF (c-Met) |
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IGF |
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LNGF (p75NTR) |
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PDGF | |||||||||||
RET (GFL) |
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SCF (c-Kit) | |||||||||||
TGFβ |
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Trk |
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VEGF |
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Others |
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