Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene.[5]
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.[5]
Miloux B, Laurent P, Bonnin O, et al. (1997). "Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex". FEBS Lett. 401 (2–3): 163–6. doi:10.1016/S0014-5793(96)01462-7. PMID9013879. S2CID85249806.
Kawakami M, Leland P, Kawakami K, Puri RK (2002). "Mutation and functional analysis of IL-13 receptors in human malignant glioma cells". Oncol. Res. 12 (11–12): 459–67. doi:10.3727/096504001108747468. PMID11939409.
Roy B, Bhattacharjee A, Xu B, et al. (2002). "IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats". J. Leukoc. Biol. 72 (3): 580–9. PMID12223527.
He JQ, Connett JE, Anthonisen NR, Sandford AJ (2003). "Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers". Am. J. Respir. Cell Mol. Biol. 28 (3): 379–85. doi:10.1165/rcmb.4885. PMID12594065.
Wongpiyabovorn J, Suto H, Ushio H, et al. (2004). "Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis". J. Dermatol. Sci. 33 (1): 31–40. doi:10.1016/S0923-1811(03)00148-8. PMID14527737.