KRT36 Identifiers Aliases KRT36 , HA6, KRTHA6, hHa6, keratin 36External IDs OMIM : 604540 MGI : 109364 HomoloGene : 88459 GeneCards : KRT36 Gene location (Human ) Chr. Chromosome 17 (human) [1] Band 17q21.2 Start 41,486,136 bp [1] End 41,492,546 bp [1]
Gene location (Mouse ) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 99,992,833 bp [2] End 99,996,452 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 17: 41.49 – 41.49 Mb Chr 11: 99.99 – 100 Mb PubMed search[3] [4] Wikidata
Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene .[5] [6] [7]
The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.[7]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000126337 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020916 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes" . J Biol Chem . 273 (41): 26683–91. doi :10.1074/jbc.273.41.26683 . PMID 9756910 .
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins" . J Cell Biol . 174 (2): 169–74. doi :10.1083/jcb.200603161 . PMC 2064177 . PMID 16831889 .
^ a b "Entrez Gene: KRT36 keratin 36" .
Further reading [ ]
Fuchs E, Weber K (1994). "Intermediate filaments: structure, dynamics, function, and disease". Annu. Rev. Biochem . 63 : 345–82. doi :10.1146/annurev.bi.63.070194.002021 . PMID 7979242 .
Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol . 101 (1 Suppl): 56S–59S. doi :10.1111/1523-1747.ep12362635 . PMID 7686952 .
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 .
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . S2CID 7827573 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle" . J. Biol. Chem . 274 (28): 19874–84. doi :10.1074/jbc.274.28.19874 . PMID 10391933 .
Proteins of the cytoskeleton
Human
Microfilaments and ABPs
Myofilament
Actins Myosins
I
II
III
V
VI
VII
IX
X
XV
XVIII
LC
Other
Actinin
Arp2/3 complex
actin depolymerizing factors
Gelsolin
Profilin
Titin
Other
Intermediate filaments
Type 1/2 (Keratin ,Cytokeratin )
Epithelial keratins (soft alpha-keratins)
type I /chromosome 17
chromosome 12
none
Hair keratins (hard alpha-keratins)Ungrouped alpha Not alpha
Type 3 Type 4 Type 5
Nuclear lamins : A/C
B1
B2
Microtubules and MAPs
Tubulins Kinesins Dyneins Other
Catenins Membrane Other
Nonhuman See also: cytoskeletal defects