Keratin 16 is a protein that in humans is encoded by the KRT16gene.[5][6][7]
Keratin 16 is a type I cytokeratin. It is paired with keratin 6 in a number of epithelial tissues, including nail bed, esophagus, tongue, and hair follicles. Mutations in the gene encoding this protein are associated with the genetic skin disorders including pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.[8]
^Rosenberg M, Fuchs E, Le Beau MM, Eddy RL, Shows TB (1991). "Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12". Cytogenet. Cell Genet. 57 (1): 33–8. doi:10.1159/000133109. PMID1713141.
Liao H, Sayers JM, Wilson NJ, et al. (2007). "A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita". J. Dermatol. Sci. 48 (3): 199–205. doi:10.1016/j.jdermsci.2007.07.003. PMID17719747.
Barcelos AC, Sotto MN (2009). "Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions". J. Cutan. Pathol. 36 (6): 647–54. doi:10.1111/j.1600-0560.2008.01127.x. PMID19515043. S2CID205816580.
Bai ZL, Feng YG, Tan SS, et al. (2008). "Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1: report of a novel and a recently reported mutation in two unrelated Chinese families". Br. J. Dermatol. 159 (1): 238–40. doi:10.1111/j.1365-2133.2008.08603.x. PMID18489596. S2CID32875094.
Bhawan J, Bansal C, Whren K, et al. (2004). "K16 expression in uninvolved psoriatic skin: a possible marker of pre-clinical psoriasis". J. Cutan. Pathol. 31 (7): 471–6. doi:10.1111/j.0303-6987.2004.0220.x. PMID15239676. S2CID20099397.
Ito Y, Kurokawa I, Nishimura K, et al. (2008). "Keratin and filaggrin expression in keratoacanthoma". J Eur Acad Dermatol Venereol. 22 (3): 353–5. doi:10.1111/j.1468-3083.2007.02440.x. PMID18005116. S2CID37712127.
Smith FJ, Fisher MP, Healy E, et al. (2000). "Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma". Exp. Dermatol. 9 (3): 170–7. doi:10.1034/j.1600-0625.2000.009003170.x. PMID10839714. S2CID44384231.
Yu JQ, Zhuang H, Xiu Y, et al. (2005). "Small urine leak after renal transplantation: detection by delayed 99mTc-DTPA renography--a case report". J Nucl Med Technol. 33 (1): 31–3. PMID15731018.
Wu C, Li C, Wei L, Zheng Z (2008). "Innate immune modulation of keratinocytes by antikeratin 16 antibodies". Exp. Dermatol. 17 (8): 645–52. doi:10.1111/j.1600-0625.2007.00682.x. PMID18557933. S2CID21212353.
Connors JB, Rahil AK, Smith FJ, et al. (2001). "Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16". Br. J. Dermatol. 144 (5): 1058–62. doi:10.1046/j.1365-2133.2001.04199.x. PMID11359398. S2CID22597662.