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MYH7B Identifiers Aliases MYH7B , MHC14, MYH14, myosin, heavy chain 7B, cardiac muscle, beta, myosin heavy chain 7BExternal IDs OMIM : 609928 MGI : 3710243 HomoloGene : 66117 GeneCards : MYH7B Gene location (Human ) Chr. Chromosome 20 (human) [1] Band 20q11.22 Start 34,955,810 bp [1] End 35,002,437 bp [1]
Gene location (Mouse ) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 155,453,132 bp [2] End 155,476,227 bp [2]
Gene ontology Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 20: 34.96 – 35 Mb Chr 2: 155.45 – 155.48 Mb PubMed search[3] [4] Wikidata
Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene .[5] [6]
Function [ ]
MYH7B is a slow-twitch myosin .[6]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000078814 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074652 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (2): 143–50. doi :10.1093/dnares/7.2.143 . PMID 10819331 .
^ a b Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family" . Mol. Biol. Evol . 19 (4): 375–93. doi :10.1093/oxfordjournals.molbev.a004093 . PMID 11919279 .
Further reading [ ]
Rossi AC, Mammucari C, Argentini C, et al. (2010). "Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles" . J. Physiol . 588 (Pt 2): 353–64. doi :10.1113/jphysiol.2009.181008 . PMC 2821527 . PMID 19948655 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71. Bibcode :2001Natur.414..865D . doi :10.1038/414865a . PMID 11780052 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
McGuigan K, Phillips PC, Postlethwait JH (2004). "Evolution of sarcomeric myosin heavy chain genes: evidence from fish" . Mol. Biol. Evol . 21 (6): 1042–56. doi :10.1093/molbev/msh103 . PMID 15014174 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Hu Z, Liang J, Wang Z, et al. (2009). "Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women". Hum. Mutat . 30 (1): 79–84. doi :10.1002/humu.20837 . PMID 18634034 . S2CID 41225773 .
Proteins of the cytoskeleton
Human
Microfilaments and ABPs
Myofilament
Actins Myosins
I
II
III
V
VI
VII
IX
X
XV
XVIII
LC
Other
Actinin
Arp2/3 complex
actin depolymerizing factors
Gelsolin
Profilin
Titin
Other
Intermediate filaments
Type 1/2 (Keratin ,Cytokeratin )
Epithelial keratins (soft alpha-keratins)
type I /chromosome 17
chromosome 12
none
Hair keratins (hard alpha-keratins)Ungrouped alpha Not alpha
Type 3 Type 4 Type 5
Nuclear lamins : A/C
B1
B2
Microtubules and MAPs
Tubulins Kinesins Dyneins Other
Catenins Membrane Other
Nonhuman See also: cytoskeletal defects
Categories :
Genes on human chromosome 20 Human chromosome 20 gene stubs