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TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBPgene.[5][6][7][8]
This gene encodes a protein that interacts with Trio, which is involved with neural tissue development and in controlling actin cytoskeleton organization, cell motility, and cell growth. This trio-binding protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminalpleckstrin homology domain and a C-terminalcoiled-coil region. Mutations in this gene have been associated with a form of autosomal-recessivenonsyndromic deafness. Multiple alternatively-spliced transcript variants that would encode different isoforms have been found for this gene, though some transcripts may be subject to nonsense-mediated decay (NMD).[8]
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