Nacolomab tafenatox
Monoclonal antibody | |
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Type | Fab fragment |
Source | Mouse |
Target | colorectal tumor antigen C242 |
Clinical data | |
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Nacolomab tafenatox is a mouse monoclonal antibody[1] designed for the treatment of colorectal cancer.[citation needed] The antibody itself, nacolomab, is fused with enterotoxin A from Staphylococcus aureus (which is reflected by 'tafenatox' in the drug's name).[1]
![](http://upload.wikimedia.org/wikipedia/commons/thumb/d/de/Fab-superantigen-fusion_protein.svg/220px-Fab-superantigen-fusion_protein.svg.png)
Schematic image of nacolomab tafenatox.
VH, VL: variable (antigen binding) domains of antibody fragment
CH1, CL: constant domains of antibody fragment
SAg: enterotoxin A (acting as a superantigen)
See also[]
- Naptumomab estafenatox, a drug with a similar chemical structure and mechanism
References[]
Categories:
- Drugs not assigned an ATC code
- Monoclonal antibodies for tumors
- Monoclonal antibody stubs
- Antineoplastic and immunomodulating drug stubs