O-demethylpuromycin O-methyltransferase

In enzymology, an O-demethylpuromycin O-methyltransferase (EC 2.1.1.38) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + O-demethylpuromycin ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + puromycin

Thus, the two substrates of this enzyme are S-adenosyl methionine and , whereas its two products are S-adenosylhomocysteine and puromycin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase. This enzyme is also called O-demethylpuromycin methyltransferase. This enzyme participates in .

References[]

• Rao MM, Rebello PF, Pogell BM (1969). "Biosynthesis of puromycin in Streptomyces alboniger. Enzymatic methylation of O-demethylpuromycin". J. Biol. Chem. 244 (1): 112–8. PMID 5773275.