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Oxolinic acid AHFS /Drugs.com International Drug Names ATC code show
5-Ethyl-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g ]quinoline- 7-carboxylic acid
CAS Number PubChem CID ChemSpider UNII KEGG ChEBI ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.035.213 Formula C 13 H 11 N O 5 Molar mass 261.233 g·mol−1 3D model (JSmol ) show
CCN1C=C(C(=O)C2=CC3=C(C=C21)OCO3)C(=O)O
show
InChI=1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)
N Key:KYGZCKSPAKDVKC-UHFFFAOYSA-N
N
N Y (what is this?)
Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s.[1] [2] Dosages 12–20 mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase . It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.[3]
See also [ ]
Amfonelic acid
Fluoroquinolone
References [ ]
^ JP Patent 49138244
^ Gleckman R, Alvarez S, Joubert DW, Matthews SJ (August 1979). "Drug therapy reviews: oxolinic acid". American Journal of Hospital Pharmacy . 36 (8): 1077–9. PMID 384788 .
^ Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J (December 1998). "Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor". European Neuropsychopharmacology . 8 (4): 255–9. doi :10.1016/S0924-977X(97)00083-7 . PMID 9928913 .
show Antifolates (inhibitspurine metabolism , thereby inhibiting DNA and RNA synthesis)
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