Phosphate acetyltransferase

Phosphate acetyltransferase
Phosphate acetyltransferase homodimer, Methanosarcina thermophila
Identifiers
EC no.	2.3.1.8
CAS no.	9029-91-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a phosphate acetyltransferase (EC 2.3.1.8) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + phosphate ${\displaystyle \rightleftharpoons }$ CoA + acetyl phosphate

The substrates of this enzyme are acetyl-CoA and phosphate, whereas its two products are CoA and .

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:phosphate acetyltransferase. Other names in common use include phosphotransacetylase, phosphoacylase, and PTA. This enzyme participates in 3 metabolic pathways: , pyruvate metabolism, and propanoate metabolism.

Structural studies[]

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1QZT, 1R5J, 1TD9, 1VMI, 1XCO, 2AF3, and 2AF4.

References[]

• BERGMEYER HU, HOLZ G, KLOTZSCH H, LANG G (1963). "Phosphotransacetylase from Clostridium Kluyveri. Culture of the Bacterium, Isolation, Crystallization and Properties of the Enzyme". Biochem. Z. 338: 114–21. PMID 14087284.
• STADTMAN ER (1952). "The purification and properties of phosphotransacetylase". J. Biol. Chem. 196 (2): 527–34. PMID 12980995.
• Stadtman ER (1955). Stadtman, ER (ed.). "Phosphotransacetylase from Clostridium kluyveri". Methods Enzymol. Methods in Enzymology. 1: 596–599. doi:10.1016/0076-6879(55)01103-8. ISBN 0-12-181801-2.