Precorrin-8X methylmutase
precorrin-8X methylmutase | |||||||||
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Identifiers | |||||||||
EC no. | 5.4.99.61 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a precorrin-8X methylmutase (EC 5.4.99.61) is an enzyme that catalyzes the chemical reaction
- precorrin-8X hydrogenobyrinate
Hence, this enzyme has one substrate, , and one product, .
This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is precorrin-8X 11,12-methylmutase. Other names in common use include precorrin isomerase, hydrogenobyrinic acid-binding protein and CobH. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in aerobic bacteria.
See also[]
Structural studies[]
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1F2V, 1I1H, 1OU0, 1V9C, 2AFR, and 2AFV.
References[]
- ^ Shipman, L. W.; Li, D.; Roessner, C. A.; Scott, A. I.; Sacchettini, J. C. (2001). "Crystal structure of precorrin-8x methyl mutase". Structure. 9 (7): 587–596. doi:10.1016/s0969-2126(01)00618-9. PMID 11470433.
- Blanche F; Couder, M; Famechon, A; Debussche, L; Cameron, B; Crouzet, J; Blanche, F (1992). "The final step in the biosynthesis of hydrogenobyrinic acid is catalyzed by the cobH gene product with precorrin-8x as the substrate". J. Bacteriol. 174 (3): 1043–9. doi:10.1128/JB.174.3.1043-1049.1992. PMC 206186. PMID 1732194.
- Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM (1993). "Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium". J. Bacteriol. 175 (11): 3303–16. doi:10.1128/jb.175.11.3303-3316.1993. PMC 204727. PMID 8501034.
- Stolowich NJ, Iida K, Scott AI (1992). "Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis". FEBS Lett. 301 (1): 73–8. doi:10.1016/0014-5793(92)80213-Z. PMID 1451790. S2CID 20198692.
- Thibaut D, Debussche L (1990). "Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid". J. Bacteriol. 172 (10): 5980–90. doi:10.1128/JB.172.10.5980-5990.1990. PMC 526920. PMID 2211521.
Categories:
- EC 5.4.99
- Enzymes of known structure
- Isomerase stubs