Precursor B-cell lymphoblastic leukemia

Precursor B-cell lymphoblastic leukemia
Precursor B-cell lymphoblastic leukemia
	A Wright's stained bone marrow aspirate smear from a person with precursor B-cell acute lymphoblastic leukemia.
Specialty	Oncology

Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia in which too many B-cell lymphoblasts (immature white blood cells) are found in the blood and bone marrow. It is the most common type of acute lymphoblastic leukemia (ALL). It is sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma.

Subtypes[]

It consists of the following subtypes:^[1]

t(9;22)-BCR/ ABL
t(v;11q23)-MLL rearrangement
t(1;19)-E2A/PBX1
t(12;21)-ETV/ CBFα
t(17;19)-E2A-HLF

Molecular Mechanisms[]

One interesting model of precursor B ALL shows aberrant function of a single gene, namely Pax5, as capable to change phenotype of B cells toward precursor cells.^[2]^[3]

Diagnosis[]

t(12;21)-ETV/ CBFα has a better prognosis as compared to other subtypes.

Treatment[]

References[]

^ Randolph TR (2004). "Advances in acute lymphoblastic leukemia". Clin Lab Sci. 17 (4): 235–45. PMID 15559730.
^ Carotta S, Nutt SL (March 2008). "Losing B cell identity". BioEssays. 30 (3): 203–7. doi:10.1002/bies.20725. PMID 18293359.
^ Den Boer ML, van Slegtenhorst M, De Menezes RX, et al. (February 2009). "A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study". Lancet Oncol. 10 (2): 125–34. doi:10.1016/S1470-2045(08)70339-5. PMC 2707020. PMID 19138562.

This article incorporates public domain material from the U.S. National Cancer Institute document: "Dictionary of Cancer Terms".

External links[]

Precursor B-lymphoblastic leukemia entry in the public domain NCI Dictionary of Cancer Terms

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[1] Randolph TR (2004). "Advances in acute lymphoblastic leukemia". Clin Lab Sci. 17 (4): 235–45. PMID 15559730.

[2] Carotta S, Nutt SL (March 2008). "Losing B cell identity". BioEssays. 30 (3): 203–7. doi:10.1002/bies.20725. PMID 18293359.

[3] Den Boer ML, van Slegtenhorst M, De Menezes RX, et al. (February 2009). "A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study". Lancet Oncol. 10 (2): 125–34. doi:10.1016/S1470-2045(08)70339-5. PMC 2707020. PMID 19138562.

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