Trichodiene synthase

From Wikipedia, the free encyclopedia
trichodiene synthase
Identifiers
EC no.4.2.3.6
CAS no.101915-76-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a trichodiene synthase (EC 4.2.3.6) is an enzyme that catalyzes the chemical reaction

trans,trans-farnesyl diphosphate trichodiene + diphosphate

Hence, this enzyme has one substrate, trans,trans-farnesyl diphosphate, and two products, and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.

Structural studies[]

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1YJ4, 1YYQ, 1YYR, 1YYS, 1YYT, 1YYU, 2AEK, 2AEL, and 2AET.

References[]

  • Hohn TM, Vanmiddlesworth F (1986). "Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides". Arch. Biochem. Biophys. 251 (2): 756–61. doi:10.1016/0003-9861(86)90386-3. PMID 3800398.


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