2-methyleneglutarate mutase

In enzymology, a 2-methyleneglutarate mutase (EC 5.4.99.4) is an enzyme that catalyzes the chemical reaction

2-methyleneglutarate ${\displaystyle \rightleftharpoons }$ 2-methylene-3-methylsuccinate

Hence, this enzyme has one substrate, , and one product, .

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-methyleneglutarate carboxy-methylenemethylmutase. This enzyme is also called alpha-methyleneglutarate mutase. This enzyme participates in . It employs one cofactor, cobamide.

References[]

• Kung HF, Cederbaum S, Tsai L, Stadtman TC (1970). "Nicotinic acid metabolism. V. A cobamide coenzyme-dependent conversion of alpha-methyleneglutaric acid to dimethylmaleic acid". Proc. Natl. Acad. Sci. U.S.A. 65 (4): 978–84. Bibcode:1970PNAS...65..978K. doi:10.1073/pnas.65.4.978. PMC 283012. PMID 5266166.
• Kung HF, Stadtman TC (1971). "Nicotinic acid metabolism. VI. Purification and properties of alpha-methyleneglutarate mutase (B 12-dependent) and methylitaconate isomerase". J. Biol. Chem. 246 (10): 3378–88. doi:10.1016/S0021-9258(18)62235-5. PMID 5574401.