Detomidine

Detomidine
Clinical data
AHFS/Drugs.com	International Drug Names
ATCvet code	QN05CM90 (WHO) ;
Legal status
Legal status	Veterinary use only;
Pharmacokinetic data
Elimination half-life	30 min
Identifiers
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CAS Number	76631-46-4 ;
PubChem CID	56032;
ChemSpider	50586 ;
UNII	7N8K34P2XH;
KEGG	D07795 ;
ChEMBL	ChEMBL2110829 ;
CompTox Dashboard (EPA)	DTXSID00227457 ;
Chemical and physical data
Formula	C12H14N2
Molar mass	186.258 g·mol−1
3D model (JSmol)	Interactive image;
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	show InChI
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Detomidine is an imidazole derivative and α₂-adrenergic agonist,^{[citation needed]} used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan.

Currently, detomidine is only licensed for use in horses in the US but it is also licensed for use in cattle in Europe and Australasia.^[1]

Properties[]

Detomidine is a sedative with analgesic properties.^[2] α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action.^[3]

Effects[]

A profound lethargy and characteristic lowering of the head with reduced sensitivity to environmental stimuli (sound, pain, etc.) are seen with detomidine. A short period of reduced coordination is characteristically followed by immobility and a firm stance with front legs spread. Following administration there is an initial increase in blood pressure, followed by bradycardia and second degree atrioventricular block (this is not pathologic in horses). The horse commonly sweats to excess, especially on the flanks and neck. Other side effects reported include pilo erection (hair standing erect), ataxia, salivation, slight muscle tremors, and (rarely) penile prolapse.

Uses[]

Sedation and anaesthetic premedication in horses and other large animals, commonly combined with butorphanol for increased analgesia and depth of sedation. In conjunction with ketamine it may also be used for intravenous anaesthesia of short duration.

The drug is normally administered by the intravenous route, and is fastest and most efficient when given intravenously . However, in recalcitrant animals, detomidine may be administered by the intramuscular or sublingual routes. The dose range advised by the manufacturers is 20–40 µg/kg intravenous for moderate sedation, but this dose may need to be higher if given intramuscularly.

When given intravenously, detomidine usually takes effect in 2–5 minutes, and recovery is full within 30–60 minutes. However, this is highly dependent upon the dosage, environment, and the individual animal; some horses are highly resistant to sedation.

Cautions[]

As detomidine is an arrhythmogenic agent, extreme care should be exercised in horses with cardiac disease, and in the concurrent administration of other arrhythmogenics. The concurrent use of potentiated sulfonamide antibiotics is considered particularly dangerous.

Detomidine is a poor premedication when using ketamine as an anesthetic in horses.

Anesthetic recoveries in horses that have received ketamine following a detomidine premedication are often violent with the horse having multiple failures to stand resulting in trauma to itself. Xylazine is a superior premedication with ketamine resulting in safer recoveries.

References[]

^ Clarke, Kathy W.; Hall, Leslie W.; Trim, Cynthia M., eds. (2014). "Principles of sedation, anticholinergic agents, and principles of premedication". Veterinary Anaesthesia. pp. 79–100. doi:10.1016/B978-0-7020-2793-2.00004-9. ISBN 978-0-7020-2793-2.
^ England GC, Clarke KW (November 1996). "Alpha 2 adrenoceptor agonists in the horse--a review". The British Veterinary Journal. 152 (6): 641–57. doi:10.1016/S0007-1935(96)80118-7. PMID 8979422.CS1 maint: uses authors parameter (link)
^ Fornai F, Blandizzi C, del Tacca M (1990). "Central alpha-2 adrenoceptors regulate central and peripheral functions". Pharmacological Research. 22 (5): 541–54. doi:10.1016/S1043-6618(05)80046-5. PMID 2177556.

External links[]

"Medication Protocols for Horses". The Ontario Association of Equine Practitioners. 2005. Archived from the original on 2007-04-17.
Compendium of data sheets for animal medicines. National Office of Animal Health. 2005. ISBN 978-0-9548037-0-4.

[1] Clarke, Kathy W.; Hall, Leslie W.; Trim, Cynthia M., eds. (2014). "Principles of sedation, anticholinergic agents, and principles of premedication". Veterinary Anaesthesia. pp. 79–100. doi:10.1016/B978-0-7020-2793-2.00004-9. ISBN 978-0-7020-2793-2.

[England_1996-2] England GC, Clarke KW (November 1996). "Alpha 2 adrenoceptor agonists in the horse--a review". The British Veterinary Journal. 152 (6): 641–57. doi:10.1016/S0007-1935(96)80118-7. PMID 8979422.CS1 maint: uses authors parameter (link)

[Fornai_1990-3] Fornai F, Blandizzi C, del Tacca M (1990). "Central alpha-2 adrenoceptors regulate central and peripheral functions". Pharmacological Research. 22 (5): 541–54. doi:10.1016/S1043-6618(05)80046-5. PMID 2177556.

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