Talipexole Trade names Domin Other names Alefexole AHFS /Drugs.com International Drug Names Routes of administration Oral ATC code Legal status
In general: ℞ (Prescription only)
6-allyl-5,6,7,8-tetrahydro-4H -[1,3]thiazolo[4,5-d ]azepin-2-amine
CAS Number PubChem CID IUPHAR/BPS ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) Formula C 10 H 15 N 3 S Molar mass 209.31 g·mol−1 3D model (JSmol )
n1c2c(sc1N)CCN(CC2)C\C=C
DIHYDROCHLORIDE: C=CCN1CCC2=C(CC1)SC(=N2)N
InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12)
N Key:DHSSDEDRBUKTQY-UHFFFAOYSA-N
N
N Y (what is this?)
Talipexole (B-HT920 , Domnin ) is a dopamine agonist that is marketed as a treatment for Parkinson's Disease in Japan by Boehringer Ingelheim ; it was introduced in 1996.[1] As of December 2014 it was not approved for marketing in the US nor in Europe.[2]
Talipexole is a D2 dopamine receptor agonist and interacts both pre- and post-synaptic receptors. It also is an α2-adrenergic agonist .[3]
The main side effects are drowsiness, dizziness, hallucinations and minor gastrointestinal complaints.[3] In 2008 the Japanese Ministry of Health, Labour, and Welfare mandated that Boehringer add a warning to the label concerning the risk of sudden onset of sleep.[4] : 15
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