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Atiprosin Other names AY-28,228 Routes of Oral ATC code
(4aR ,12bS )-1-ethyl-12-methyl-4-(propan-2-yl)-1,2,3,4,4a,5,6,12b-octahydropyrazino[2',3':3,4]pyrido[1,2-a]indole
CAS Number PubChem CID ChemSpider UNII ChEMBL Formula C 20 H 29 N 3 Molar mass −1 3D model (JSmol )
n23c1ccccc1c(c2[C@H]4N(CCN([C@@H]4CC3)C(C)C)CC)C
InChI=1S/C20H29N3/c1-5-21-12-13-22(14(2)3)18-10-11-23-17-9-7-6-8-16(17)15(4)19(23)20(18)21/h6-9,14,18,20H,5,10-13H2,1-4H3/t18-,20+/m1/s1
Y Key:WXNVFYIBELASJW-QUCCMNQESA-N
Y N Y (what is this?)
Atiprosin (developmental code name AY-28,228 ) is an antihypertensive agent which acts as a selective α1 -adrenergic receptor antagonist .[1] [2] [3] [4] antihistamine activity, though it is some 15-fold weaker in this regard than as an alpha blocker .[3] [1]
See also [ ] References [ ]
^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents ISBN 0-412-46630-9 ^ Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry . 30 (2): 388–94. doi :10.1021/jm00385a022 . PMID 3806618 . ^ a b Grimes D, Rimele TJ, Henry DE, et al. (September 1987). "In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound". Journal of Cardiovascular Pharmacology . 10 (3): 249–58. doi :10.1097/00005344-198709000-00001 . PMID 2444771 . S2CID 9361176 . ^ Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). "Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys". Journal of Cardiovascular Pharmacology . 10 (3): 341–9. doi :10.1097/00005344-198709000-00014 . PMID 2444784 . S2CID 19086175 .
External links [ ] Atiprosin at Wikimedia Commons
Sympatholytic (and closely related) antihypertensives (C02 )
Sympatholytics α-adrenergic vasoconstriction )
Central
α2 -Adrenergic receptor agonists
Clonidine Guanabenz Guanfacine Guanoxabenz Methyldopa # Tiamenidine ‡ Adrenergic release inhibitors
Bethanidine Bretylium Debrisoquine Guanadrel Guanazodine Guanethidine Guanoclor Guanoxan Imidazoline receptor agonists
Moxonidine Rilmenidine Tolonidine Ganglion-blocking /nicotinic antagonists
Peripheral
Indirect
Monoamine oxidase inhibitors VMAT inhibitors
Bietaserpine Deserpidine Methoserpidine Reserpine Syrosingopine Tyrosine hydroxylase inhibitors
Direct
α1 -Adrenergic receptor blockers
Doxazosin Ketanserin Indoramin Prazosin Trimazosin Urapidil Non-selective α-adrenergic receptor blockers
Other antagonists
# WHO-EM ‡ Withdrawn from marketClinical trials :
† Phase III § Never to phase III
α1
Agonists Antagonists
Abanoquil Ajmalicine Alfuzosin Anisodamine Anisodine Atiprosin Atypical antipsychotics (e.g., brexpiprazole , clozapine , olanzapine , quetiapine , risperidone )Benoxathian Beta blockers (e.g., adimolol , amosulalol , arotinolol , carvedilol , eugenodilol , labetalol )Buflomedil Bunazosin Corynanthine Dapiprazole Domesticine Doxazosin Ergolines (e.g., acetergamine , ergotamine , dihydroergotamine , lisuride , nicergoline , terguride )Etoperidone Fenspiride Hydroxyzine Indoramin Ketanserin L-765,314 mCPP Mepiprazole Metazosin Monatepil Moxisylyte Naftopidil Nantenine Neldazosin Niaprazine Niguldipine Pardoprunox Pelanserin Perlapine Phendioxan Phenoxybenzamine Phentolamine Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Piperoxan Prazosin Quinazosin Quinidine Silodosin Spegatrine Spiperone Talipexole Tamsulosin Terazosin Tiodazosin Tolazoline Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin )Tricyclic antidepressants (e.g., amitriptyline , clomipramine , doxepin , imipramine , trimipramine )Trimazosin Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )Urapidil WB-4101 Zolertine
α2
Agonists
(R)-3-Nitrobiphenyline 4-NEMD 6-FNE Amitraz Apraclonidine Brimonidine Clonidine Corbadrine Deoxyepinephrine (epinine, N -methyldopamine) Detomidine Dexmedetomidine Dihydroergotamine Dipivefrine Dopamine Droxidopa (L -DOPS) Etilevodopa Ergotamine Epinephrine Etilefrine Ethylnorepinephrine Guanabenz Guanfacine Guanoxabenz L -DOPA (levodopa)L -PhenylalanineL -TyrosineIbopamine Lofexidine Medetomidine Melevodopa Methyldopa Mivazerol Moxonidine Naphazoline Norepinephrine Oxymetazoline Phenylpropanolamine Piperoxan Rilmenidine Romifidine Talipexole Tetrahydrozoline Tiamenidine Tizanidine Tolonidine Urapidil Xylazine Xylometazoline Antagonists
1-PP Adimolol Amesergide Aptazapine Atipamezole Atypical antipsychotics (e.g., asenapine , brexpiprazole , clozapine , lurasidone , olanzapine , paliperidone , quetiapine , risperidone , zotepine )Azapirones (e.g., buspirone , gepirone , ipsapirone , tandospirone )BRL-44408 Buflomedil Cirazoline Efaroxan Esmirtazapine Fenmetozole Fluparoxan Idazoxan Ketanserin Lisuride mCPP Mianserin Mirtazapine NAN-190 Pardoprunox Phentolamine Phenoxybenzamine Piperoxan Piribedil Rauwolscine Rotigotine Setiptiline Spegatrine Spiroxatrine Sunepitron Terguride Tolazoline Typical antipsychotics (e.g., chlorpromazine , fluphenazine , loxapine , thioridazine )Yohimbine
β
See also: Receptor/signaling modulators Dopaminergics Serotonergics Monoamine reuptake inhibitors Monoamine releasing agents Monoamine metabolism modulators Monoamine neurotoxins
H1
Agonists
2-Pyridylethylamine Betahistine Histamine HTMT L -HistidineUR-AK49 Antagonists
Others: Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , brilaroxazine , clozapine , iloperidone , olanzapine , paliperidone , quetiapine , risperidone , ziprasidone , zotepine )Phenylpiperazine antidepressants (e.g., hydroxynefazodone , nefazodone , trazodone , triazoledione )Tetracyclic antidepressants (e.g., amoxapine , loxapine , maprotiline , mianserin , mirtazapine , oxaprotiline )Tricyclic antidepressants (e.g., amitriptyline , butriptyline , clomipramine , desipramine , dosulepin (dothiepin) , doxepin , imipramine , iprindole , lofepramine , nortriptyline , protriptyline , trimipramine )Typical antipsychotics (e.g., chlorpromazine , flupenthixol , fluphenazine , loxapine , perphenazine , prochlorperazine , thioridazine , thiothixene )
H2
H3
Agonists
α-Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine L -HistidineMethimepip Proxyfan Antagonists
H4
Agonists
4-Methylhistamine α-Methylhistamine Histamine L -HistidineOUP-16 VUF-8430 Antagonists
See also: Receptor/signaling modulators • Monoamine metabolism modulators • Monoamine reuptake inhibitors
Tricyclics
Classes Antidepressants (TCAs and TeCAs ) Antihistamines Antipsychotics Anticonvulsants Others
Categories :
Drugs not assigned an ATC code Abandoned drugs Alpha-1 blockers Antihistamines Antihypertensive agents Indoles Isopropyl compounds Piperazines Antihypertensive agent stubs Hidden categories:
Articles with changed CASNo identifier Articles with changed EBI identifier Chemical pages without DrugBank identifier Articles without KEGG source Drugs with no legal status Drugboxes which contain changes to verified fields Drugboxes which contain changes to watched fields Commons category link from Wikidata All stub articles
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