Tampramine Routes of administration Oral Legal status
N ,N -Dimethyl-3-(6-phenylpyrido[2,3-b ][1,4]benzodiazepin-11-yl)propan-1-amine
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) Formula C 23 H 24 N 4 Molar mass 356.473 g·mol−1 3D model (JSmol )
CN(C)CCCN1c2ccccc2C(=Nc3c1nccc3)c4ccccc4
Tampramine (AHR-9,377 ) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.[1] [2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic , histaminergic , and muscarinic receptors .[1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.[2]
See also [ ]
References [ ]
^ a b Kinnier WJ, Tabor RD, Norrell LY (October 1984). "Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake". Biochemical Pharmacology . 33 (19): 3001–5. doi :10.1016/0006-2952(84)90600-2 . PMID 6548381 .
^ a b O'Donnell JM, Seiden LS (1985). "Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate". Psychopharmacology . 87 (3): 283–5. doi :10.1007/BF00432708 . PMID 3936083 . S2CID 20677730 .
Antidepressants (N06A )
SSRIs
Citalopram
Escitalopram
Fluoxetine #
Fluvoxamine
Indalpine ‡
Paroxetine
Sertraline
Zimelidine ‡
SNRIs
Desvenlafaxine
Duloxetine
Levomilnacipran
Milnacipran
Tofenacin
Venlafaxine
NRIs
Atomoxetine
Reboxetine
Viloxazine
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Amineptine ‡
Bupropion
Nomifensine ‡
NaSSAs SARIs
Etoperidone
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Trazodone
SMS Others
Tricyclic and tetracyclic antidepressants
TCAs
Amineptine ‡
Amitriptyline #
Amitriptylinoxide
Butriptyline ‡
Clomipramine #
Demexiptiline ‡
Desipramine
Dibenzepin
Dimetacrine ‡
Dosulepin
Doxepin
Imipramine
Imipraminoxide ‡
Iprindole ‡
Lofepramine
Melitracen
Metapramine ‡
Nitroxazepine
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Noxiptiline
Opipramol
Pipofezine
Propizepine ‡
Protriptyline
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Miscellaneous
Ademetionine (SAMe )
Hypericum perforatum (St. John's Wort)
Oxitriptan (5-HTP )
Rubidium chloride (RbCl)
Tryptophan
# WHO-EM
‡ Withdrawn from market
Clinical trials :
† Phase III
§ Never to phase III
α1
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BRL-44408
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β
See also: Receptor/signaling modulators
Dopaminergics
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Monoamine reuptake inhibitors
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Monoamine neurotoxins
Tricyclics
Classes Antidepressants (TCAs and TeCAs ) Antihistamines Antipsychotics Anticonvulsants Others