Chemical compound
Abediterol Routes of administration Inhalation ATC code Elimination half-life 24.3 hours[1]
5-[(1R )-2-{[6-(2,2-Difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl]-8-hydroxyquinolin-2(1H )-one
CAS Number PubChem CID ChemSpider UNII KEGG ChEBI ChEMBL CompTox Dashboard (EPA ) Formula C 25 H 30 F 2 N 2 O 4 Molar mass 460.522 g·mol−1 3D model (JSmol )
FC(F)(c1ccccc1)COCCCCCCNC[C@H](O)c3ccc(O)c2c3\C=C/C(=O)N2
InChI=1S/C25H30F2N2O4/c26-25(27,18-8-4-3-5-9-18)17-33-15-7-2-1-6-14-28-16-22(31)19-10-12-21(30)24-20(19)11-13-23(32)29-24/h3-5,8-13,22,28,30-31H,1-2,6-7,14-17H2,(H,29,32)/t22-/m0/s1
Y Key:SFYAXIFVXBKRPK-QFIPXVFZSA-N
Y
Abediterol (INN ;[2] development codes AZD-0548 and LAS 100977) is a once-daily experimental drug candidate for the treatment of asthma and chronic obstructive pulmonary disease (COPD). It is currently under development by the Spanish pharmaceutical company Almirall and is in Phase II clinical trials.[3] [4]
It acts as a dual β2 adrenergic agonist [5] [6] and muscarinic antagonist and is classified as an ultra-long-acting β2 agonist (ultra-LABA).[7]
Its coformulation with mometasone furoate is also in Phase II clinical trials.[8] [when? ] [needs update ]
References [ ]
^ Timmer W, Massana E, Jimenez E, Seoane B, de Miquel G, Ruiz S (December 2014). "First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of abediterol (LAS100977), a novel long-acting Β2 -agonist". Journal of Clinical Pharmacology . 54 (12): 1347–53. doi :10.1002/jcph.355 . PMID 24989946 . S2CID 20959248 .
^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed International Nonproprietary Names: List 104" (PDF) . WHO Drug Information . 24 (1): 352. 2010. Retrieved 25 March 2016 .
^ Product development pipeline , Almirall
^ "AdisInsight: Abediterol" . Adis Insight . Springer International Publishing AG. Retrieved 25 March 2016 .
^ "Espacenet - Bibliographic data" . worldwide.espacenet.com . Retrieved 2021-05-07 .
^ "Espacenet - Bibliographic data" . worldwide.espacenet.com . Retrieved 2021-05-07 .
^ Beier J, Fuhr R, Massana E, Jiménez E, Seoane B, de Miquel G, Ruiz S (October 2014). "Abediterol (LAS100977), a novel long-acting β2-agonist: efficacy, safety and tolerability in persistent asthma" . Respiratory Medicine . 108 (10): 1424–9. doi :10.1016/j.rmed.2014.08.005 . PMID 25256258 .
^ "AdisInsight: Abediterol/mometasone" . Adis Insight . Springer International Publishing AG. Retrieved 25 March 2016 .
Drugs for obstructive airway diseases : asthma /COPD (R03 )
Adrenergics , inhalants
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‡ Withdrawn from market
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§ Never to phase III
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See also: Receptor/signaling modulators
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Abediterol
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See also: Receptor/signaling modulators • Nicotinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators